Description
Indications
Memantine is used to treat all types of dementia, including Alzheimer’s disease. Other types of dementia may also benefit from memantine treatment.
Pharmacology
Diligent actuation of N-methyl-D-aspartate (NMDA) receptors in the Central Anxious Framework by the excitatory amino corrosive glutamate has been hypothesized to contribute to the symptomatology of Alzheimer’s illness. Memantine is hypothesized to apply its helpful impact through its activity as a moo to direct fondness as an uncompetitive (open-channel) NMDA receptor opponent which ties especially to the NMDA receptor-operated cation channels.
Administration & Dosage
The recommended maintenance dose of Memantine for adults and older patients is 20 mg every day. In order to lower the risk of side effects, the dose should be achieved by upward titration with 5 mg per week over 3 weeks, achieving the maintenance dose of 20 mg/day from the start of week 4 according to the following dosage guideline:
Week 1 (Everyday): Morning- 5 mg (1 tablet), Night- No dose
Week 2 (Everyday): Morning- 5 mg (1 tablet), Night- 5 mg (1 tablet)
Week 3 (Everyday): Morning- 10 mg (2 tablets), Night- 5 mg (1 tablet)
Week 4 and onwards (Everyday): Morning- 10 mg (2 tablets), Night- 10 mg (2 tablets)
Missed Dose: If any dose is missed, just wait and take the next dose at the usual time. Do not double the dose to compensate for the missed dose.
Interaction
Anticholinergics, Anticonvulsives, Baclofen, Barbiturates, Cimetidine, Dantrolene, Dextromethorphan, Dopaminergic, Hydrochlorothiazide, Ketamine, Neuroleptics, Nicotine, Procainamide, Quinidine, Quinine, Ranitidine, Quinidine, Quinine, Ranitidine
Contraindications
Patients who have a known hypersensitivity to Memantine Hydrochloride or any of the excipients used in the formulation should not take it.
Side Effect
Hallucination, confusion, dizziness, headache, and fatigue are the most common side effects (frequency of 2% or less). Anxiety, hypertonus (heightened muscle tension), vomiting, bladder infections, and increased sexual drive are all possible side effects. If you have a history of epileptic seizures, Memantine may increase your chances of having one.
Pregnancy & Lactation
Pregnancy Category B. However there are no satisfactory and well-controlled considerations of Memantine in pregnant ladies. Memantine ought to be utilized amid pregnancy as it were in the event that the potential advantage legitimizes the potential hazard to the hatchling. It isn’t known whether Memantine is excreted in the human breast drain. Since numerous drugs are excreted in the human brain, caution ought to be worked out when Memantine is managed by a nursing mother.
Precautions & Warnings
Drugs for Dementia, Anti-Drugs Alzheimer’s
Therapeutic Class
SSRIs and other antidepressant medications
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.
