Generic

Sildenafil Citrate

Indications

Sildenafil is suitable for the treatment of erectile dysfunction.

Pharmacology

Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and is used to treat erectile dysfunction. Danafil (sildenafil) enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for the degradation of cGMP in the cavernous body, leading to smooth muscle relaxation and blood flow to the sponge Body.

Dosage & Administration

The recommended dose of Sildenafil is 50 mg collected approximately one hour before sexual activity. However, Sildenafil can be taken from 30 hours to 4 hours of sexual activity. On the basis of effectiveness and tolerance, the dose can increase up to 100 mg or decrease at 25 mg. The frequency of maximum recommended administration is once a day.

Interaction

Simultaneous use of sildenafil and organic nitrates for angina pectoris can cause hypotension. Cimetidine, a drug used to treat gastric ulcers, some antibiotics such as erythromycin and rifampicin, and some protease inhibitors such as ritonavir and saquinavir, are used to treat HIV infection. Denafil increases plasma concentration. Some drugs used to treat fungal infections, such as ketoconazole and itraconazole, can reduce the clearance of sildenafil.

Contraindications

Sildenafil is contraindicated in patients who are allergic to any component of sildenafil. Sildenafil can enhance the antihypertensive effect of nitrate drugs, so patients who take organic nitrate drugs regularly or intermittently are contraindicated.

Side Effects

Side effects of sildenafil treatment include headache, flushing, indigestion, nasal congestion, urinary tract infection, abnormal vision, diarrhea, dizziness, and rash.

Pregnancy & Lactation

Grade B pregnancy. There are no adequate and well-controlled studies on the use of sildenafil in pregnant women. Sildenafil is not suitable for women. In animal studies, sildenafil has been shown to have no evidence of teratogenicity or embryotoxicity.

Precautions & Warnings

Patients should proceed with caution if they are allergic to any other drugs or any other substances (such as food, preservatives or dyes), heart or blood vessel problems, or sudden blindness in one or both eyes. If the patient has any of the following diseases, such as diabetes, kidney or liver problems, leukemia, multiple myeloma, any disease or malformation of the penis, any bleeding disorder such as hemophilia, gastric ulcer, sickle cell anemia, you should be cautious Acting, color perception. Hearing problems, reduced or sudden loss or any other treatment for impotence.

Therapeutic Class

Drugs for Erectile Dysfunction

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.