Description
Indications
Clobetasol Propionate is used to treat the following dermatoses in adults, the elderly, and children over the age of one year.
- Psoriasis is a skin condition that affects people of all ages (excluding widespread plaque psoriasis)
- Dermatoses that refuse to go away
- Lichen planus is a kind of lichen that grows on the
- Discoid lupus erythematosus is a kind of lupus erythematosus.
- Other skin problems that don’t react well to less powerful steroids
Pharmacology
Clobetasol Propionate is a topical corticosteroid with a high potency. It works as an anti-inflammatory, anti-pruritic, and vasoconstrictor. It inhibits late-phase allergic responses by exhibiting anti-inflammatory effects through several pathways. Mast cell density, chemotaxis, and eosinophil activation are all reduced. It also inhibits arachidonic acid metabolism and decreases cytokine production.
Dosage
Administration
Interaction
Corticosteroid metabolism has been found to be inhibited by co-administered medications that inhibit CYP3A4 (e.g., ritonavir, itraconazole), resulting in increased systemic exposure.
Contraindications
It is not recommended for patients who have a hypersensitivity to any of the preparation’s ingredients. Rosacea, acne vulgaris, perioral dermatitis, perianal and vaginal pruritus, pruritus without inflammation, and untreated skin diseases are all contraindications.
Side Effects
Burning and stinging sensations are the most commonly reported adverse effects. Itching, skin atrophy, cracking, and fissuring of the skin are less common side effects. Long-term usage of topical Clobetasol Propionate formulations has been linked to Cushing syndrome in both children and adults.
Pregnancy & Lactation
The use of Clobetasol Propionate cream in pregnant women has had mixed results. Corticosteroids used topically in pregnant animals can induce fetal development problems. The applicability of this discovery to people has yet to be determined. Clobetasol Propionate Cream administration during pregnancy and breastfeeding, on the other hand, should only be undertaken if the predicted benefit to the mother surpasses the potential hazards of therapy.
This medication is not known to be excreted in human milk. When Clobetasol Propionate Cream is given to a breastfeeding mother, care should be used because many medications are excreted in human milk.
Precautions & Warnings
When using occlusive dressings, the skin should be cleaned before applying a new dressing. In psoriasis, topical corticosteroids should be administered with caution since they can cause rebound relapses and local or systemic toxicity due to decreased skin barrier function. Treatment should be restricted to 5 days if applied on the face. When using Clobetasol Propionate on eyelids, be careful not to get it in your eyes, as this might cause cataracts and glaucoma.
Therapeutic Class
Storage Conditions
Keep the temperature below 30°C and away from light and moisture. Do not allow yourself to get frozen. Keep out of children’s reach.
