Indications

This is indicated in-

• Productive cough
• Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus including acute and chronic bronchitis
• Inflammatory disease of rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis and rhinitis) associated with viscid mucus
• Asthmatic bronchitis bronchial asthma with thick expectoration
• Bronchiectasis
• Chronic pneumonia etc.

Pharmacology

Ambroxol is the dynamic metabolite of bromhexine and it has been demonstrated that this metabolite has a more noteworthy bronchosecretolytic impact than bromhexine. It moves forward sputum rheology by hydrating instrument driving to liquefaction of bodily fluid within the lumen of respiratory tract, hence encouraging expectoration of bodily fluid and diminishing dyspnea. It invigorates generation of phospholipids of surfactant by alveolar cells, hence contributing to the lowering of shallow pressure within the alveoli. It moreover decreases bronchial hyperactivity. Ambroxol has hostile to fiery properties owing to the inhibitory impact on the generation of cellular cytokines and arachidonic corrosive metabolites. In patients with COPD it customarily makes strides aviation route patency.

Dosage & Administration

Average daily dose (preferably after meal):

Pediatric Drops:

▪ 0-6 months: 0.5 ml 2 times a day

▪ 6-12 months: 1 ml 2 times a day

▪ 1-2 years: 1.25 ml 2 times a day

Syrup:

▪ 2-5 years: 2.5 ml (1/2 teaspoonful)

2-3 times a day

▪ 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day

▪ 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.

Sustained release capsule:

▪ Adult and children over 12 years old: 1 capsule once daily

Specific application features: X-Cold 100 ml may be prescribed to patients suffering from diabetes mellitus.

Interaction

Antitussives (e.g. Codeine) should not be taken with Ambroxol because phlegm that has been dissolved by Ambroxol may not be expectorated.

Contraindications

Ambroxol or Bromhexine hypersensitivity is contraindicated.

Side Effects

Gastrointestinal side effects such as epigastric discomfort and a sense of stomach overfilling may occur on occasion. Allergic reactions such as eruption, urticaria, and angioneurotic edema have been observed on rare occasions.

Pregnancy & Lactation

X-Cold 100 ml has been found to have no teratogenic or fetal toxicity in tests. It is not recommended for use during pregnancy, especially during the first trimester. It is yet to be determined whether or not it is safe to use during lactation.

Precautions & Warnings

Patients with stomach and duodenal ulcers, as well as convulsive disorders, should use X-Cold 100 ml with caution. It should be used with caution by patients who have hepatic or renal impairment.

Therapeutic Class

Cough expectorants & mucolytics

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Pharmaceutical Name

ACME Laboratories Ltd

Generic

Ambroxol Hydrochloride