Generic

Moxifloxacin Hydrochloride

Indications

Acute bacterial sinusitis, acute aggravation of chronic bronchitis, community-acquired pneumonia, uncomplicated and complicated skin and skin structure infections, complicated intra-abdominal infections, and pelvic inflammatory disease are among the conditions for which moxifloxacin is prescribed.

Pharmacology

Moxifloxacin belongs to the fluoroquinolone class of antibacterial drugs, and it is a 4th generation synthetic broad spectrum antibacterial medication. It works against a wide spectrum of bacteria, including Mycoplasma pneumoniae, that are gram-positive, gram-negative, anaerobic, and atypical. Topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, and repair, are inhibited.

Dosage & Administration

Acute bacterial sinusitis: 400 mg once daily 7-10 days.
Acute bacterial exacerbation of chronic bronchitis: 400 mg once daily 5-10 days.
Community-acquired pneumonia: 400 mg once daily 7-14 days.
Uncomplicated skin and skin structure infections: 400 mg once daily 7 days.
Complicated skin and skin structure infections: 400 mg once daily 7-21 days.
Complicated intra-abdominal infections: 400 mg once daily 5-14 days.
Pelvic inflammatory disease: 400 mg once daily 14 days.

Interaction

When antacids, sucralfate, multivitamins, and multivalent cations are used together, moxifloxacin absorption is reduced (e.g. iron or zinc). With NSAIDs and warfarin, moxifloxacin may increase the risk of convulsions and bleeding. As a result, using Moxifloxacin with them at the same time should be avoided.

Contraindications

Patients having a history of hypersensitivity to Moxifloxacin or other quinolones should avoid it.

Side Effects

Nausea, vomiting, diarrhea, headaches, and dizziness are all common Moxifloxacin side effects.

Pregnancy & Lactation

Pregnancy category C according to the US Food and Drug Administration. During pregnancy and nursing, moxifloxacin is not indicated.

Precautions & Warnings

Tendinitis and tendon rupture are possible side effects of moxifloxacin. If a tendon becomes inflamed or painful, it should be stopped. It should not be used in individuals who have a known prolongation of the QT interval, hypokalemia that has not been addressed, or who are taking Class IA or Class III antiarrhythmics.

Therapeutic Class

Preparations containing four quinolones.

Storage Conditions

Store away from light and heat in a cool, dry location. Children should be kept out of reach.

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.