Description
Generic
Indications
Voglibose is used in the treatment of diabetes mellitus (DM) to reduce Post-Prandial Hyperglycemia (PPHG), but only when diet and/or exercise, along with lifestyle changes or oral hypoglycemic agents (OHAs) or insulin preparations, do not result in adequate glycemic control.
Pharmacology
Alpha-glucosidase inhibitors are saccharides that act as competitive inhibitors of carbohydrate-digesting enzymes, specifically alpha-glucosidase enzymes in the small intestine’s brush border. In the small intestine, oligosaccharides, trisaccharides, and disaccharides are hydrolyzed to glucose and other monosaccharides by membrane-bound intestinal alpha-glucosidases.
Dosage & Administration
Adult Dose: Voglibose tablets are usually taken three times a day, before each meal, in a single dose of 0.2 mg. If the effect is insufficient, the single dose quantity can be increased up to 0.3 mg.
Interaction
For the simultaneous use of antldlabetlc drugs and drugs that enhance or diminish antldlabetlc drugs’ hypoglycaemic action:
-blockers, salicylic acid preparations, monoamine oxidase inhibitors, fibrate derivatives for the treatment of hyperlipemia, warfarin, and other drugs that enhance the hypoglycaemic action of antidiabetic drugs
Contraindications
Patients with hypersensitivity to Voglibose or any of the excipients should not take this medication. Diabetic ketoacidosis and diabetic pre-coma are both symptoms of diabetic ketoacidosis. Severe infection, both before and after surgery, or as a result of serious trauma; Obstruction of the gastrointestinal tract or a predisposition to it.
Side Effects
Diarrhoea, loose stools, abdominal pain, constipation, loss of appetite, nausea, vomiting, heartburn, increased gas, and intestinal obstruction-like symptoms due to increased intestinal gas are all symptoms of increased intestinal gas. Hypoglycemia (0.1 percent to 5%) and a delay in disaccharide digestion and absorption may occur when OHAs are combined with voglibose.
Pregnancy & Lactation
Pregnancy: The safety of Voglibose during pregnancy has yet to be determined. However, no adequate and well-controlled studies on pregnant women have been conducted.
Lactating and nursing mothers: Despite the fact that the levels of Voglibose found in human milk are extremely low, it is not recommended that Voglibose be given to these women.
Precautions & Warnings
Careful Administration (should be given with caution to subsequent patients):
Patients taking other anti-diabetic medications, as hypoglycemia can occur.
Patients who have had a laparotomy or have had an ileus (intestinal obstruction-like symptoms are liable to develop due to an increase in intestinal gas, etc.)
Patients with a digestive disturbance due to chronic intestinal disease.
Therapeutic Class
Inhibitor of alpha-glucosidase
Storage Conditions
Keep the temperature below and away from light and moisture. Keep out of children’s reach.
