Uropass-D 0.4 MG /0.5 MG


Uropass-D 0.4 MG /0.5 MG


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Tamsulosin Hydrochloride



Tamsulosin Hydrochloride is a medication used to treat the symptoms of benign prostatic hyperplasia (BPH).



Tamsulosin, a specific alpha1 adrenoceptor blocking specialist, shows its selectivity for alpha1 A adrenoceptors in human prostate. Barricade of these adrenoceptors can cause smooth muscle within the bladder neck and prostate to unwind, coming about in an enhancement in pee stream rate and a diminishment in indications of BPH. Assimilation of Tamsulosin hydrochloride capsule 0.4mg is basically total (90%) taking after verbal organization beneath fasting conditions. The time to most extreme concentration (Tmax) is come to by four to five hours beneath fasting conditions and by six to seven hours when managed with nourishment. Tamsulosin hydrochloride is greatly bound to human plasma protein (94% to 99%). Tamsulosin hydrochloride is broadly metabolized by cytochrome P 450 proteins within the liver and less than 10% of the measurements is excreted in pee as unaltered shape. Taking after intravenous or verbal organization of an immediate-release definition the disposal half-life of Tamsulosin hydrochloride in plasma ranges from five to seven hours. Since of the retention rate controlled pharmacokinetics with Prostam capsules, the clear half-life of Tamsulosin hydrochloride is roughly 9 to 13 hours in sound volunteers and 14 to 15 hours within the target populace.


Dosage & Administration

Tamsulosin Hydrochloride 0.4 mg (one capsule) daily, to be taken after meal at night. The dose may be increased after 2 to 4 weeks, if necessary, to Tamsulosin Hydrochloride 0.8 mg (two capsules) once daily. If Tamsulosin Hydrochloride administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, therapy should be started again with the Tamsulosin Hydrochloride 0.4 mg (one capsule) once daily dose. The capsule should be swallowed whole with a glass of water (about 150 ml) in the standing or sitting position. The capsule should not be crunched or chewed, as this will interfere with the modified release of the active ingredient.



Concurrent organization of other alfa1-adrenoceptor enemies might lead to hypotensive impacts. No intelligent have been seen when Tamsulosin was given concomitantly with either atenolol, enalapril or nifedipine. Concomitant cimetidine brings around a rise and frusemide a drop in plasma levels of Tamsulosin, but as levels stay inside the ordinary extend posology require not be changed. No intuitive at the level of hepatic digestion system have been seen amid in vitro thinks about with liver microsomal divisions (agent of the cytochrome P450-linked drug-metabolizing protein framework), including amitriptyline, salbutamol, glibenclamide, and finasteride. Diclofenac and warfarin, in any case, may increment the disposal rate of Tamsulosin.



Patients with hypersensitivity to tamsulosin hydrochloride, a history of orthostatic hypotension, or severe hepatic insufficiency should not use it.

As with other alpha1 blockers, a decrease in blood pressure can occur in rare situations during therapy with Tamsulosin, leading to syncope. If the patient experiences the first signs of orthostatic hypotension (dizziness, weakness), he or she should sit or lie down until the symptoms disappear. They should also be warned to avoid circumstances that could end in injury (like driving, operating machinery or performing hazardous tasks). H).

Some time recently treatment with Tamsulosin is started the understanding ought to be inspected in arrange to avoid the nearness of other conditions which can cause the same side effects as Generous Prostatic hyperplasia. Computerized rectal examination and when the vital assurance of Prostate Particular Antigen (PSA) ought to be performed some time recently treatment and at normal interims a short time later.


Side Effects

Dizziness, abnormal ejaculation, and, less commonly, headache, asthenia, postural hypotension, and palpitations have all been described as side effects of Tamsulosin use.


Pregnancy & Lactation

Tamsulosin should not be used during pregnancy or nursing.


Precautions & Warnings

During orthostatic provocation testing following the initial dose, temporary postural symptoms have occurred on rare occasions. It is not recommended for use in people who have micturition syncope.

Effects on ability to drive and operate equipment: There is no evidence that Tamsulosin impairs one’s ability to drive or operate machines. Patients should be informed, however, that dizziness can arise in this situation.


Therapeutic Class

BPH/ Urinary retention/ Urinary incontinence


Storage Conditions

Store in a cool and dry place, below 30°C, protected from light.


Pharmaceutical Name

ACME Laboratories Ltd.