Indications

This ointment is used to treat hyperkeratotic and dry corticosteroid-responsive dermatoses like psoriasis, chronic atopic dermatitis, neurodermatitis (lichen Simplex, Chronicus), lichen planus, eczema (including nummular eczema, hand eczema, eczematous dermatitis), seborrheic dermatitis of the scalp

Pharmacology of Topiclo S 20 Ointment

High-potency corticosteroid Clobetasol Propionate. Corticosteroids reduce inflammation by stabilizing leukocyte lysosomal membranes, preventing the release of destructive acid hydrolases from leukocytes, inhibiting macrophage accumulation in inflamed areas, reducing leukocyte adhesion to capillary endothelium, reducing capillary wall permeability and edema formation, decreasing complement components, and antagonizing histamine activity and kinectin release.

When administered topically, salicylic acid has a strong keratolytic and antiseptic effect. By boosting endogenous hydration, it softens and destroys the stratum corneum, causing the horny layer of the skin to enlarge, soften, and finally desquamate. Salicylic acid has a caustic impact at high concentrations. It also has some antifungal and antibacterial properties.

Dosage & Administration of Topiclo S 20 Ointment

Adult: Apply a thin layer of this ointment to the affected skin areas twice daily and rub in gently & completely. For some patients, adequate maintenance therapy may be achieved with less frequent application. As with other higher active corticosteroids, therapy should be discontinued when control has been achieved. If no improvement is seen within 2 weeks, reassessment of diagnosis may be necessary. It should not be used with an occlusive dressing. Treatment beyond 2 consecutive weeks is not exceeding 50 gm/week because of the potential for the drug to suppress the hypothalamic pituitary adrenal axis.

Children: Use in pediatric patients under 12 years of age is not recommended.

Interaction of Topiclo S 20 Ointment

There has been no report of interaction with Clobetasol Propionate treatment and cream. There is no known intelligence of Salicylic Corrosive when utilized as demonstrated. In any case, topical salicylic corrosive may increment the assimilation of other topically connected drugs. Concomitant utilization of Salicylic Corrosive Treatment and other topical drugs on the same range of skin ought to subsequently be avoided.

Contraindications

ClobetasolPropionatev is not recommended for people who are allergic to Clobetasol Propionate. This medication is also contraindicated in the treatment of primary infected bacterial or fungal skin lesions when no anti-infective therapy is administered at the same time, in primary cutaneous viral infections (such as herpes simplex, vaccinia, and varicella), and in tuberculous skin lesions. Clobetasol Propionate is also contraindicated in children under the age of one year with dermatoses such as dermatitis and diaper eruptions. In individuals with salicylate hypersensitivity or sensitivity to any other constituent in the preparation, salicylic acid is contraindicated.

Side effects of Topiclo S 20 Ointment

As with other topical corticosteroids, prolonged use of large amounts of Clobetasol Propionate or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercortisolism.

Pregnancy & Lactation

Topical administration of corticosteroids to pregnant animals can cause abnormalities in fetal development. The relevance of this finding to human beings has not been established. The safe use of Clobetasol Propionate during lactation has not been established.

Precautions & Warnings

Not for prolonged use in high concentrations and on large areas of the body.

Therapeutic Class

Clobetasol / Clobetasone & Combined Preparations

Storage Conditions

Keep in a dry place away from light and heat.

Pharmaceutical Name of Topiclo S 20 Ointment

Eskayef Pharmaceuticals Ltd

Generic of Topiclo S 20 Ointment

Clobetasol Propionate + Salicylic Acid