Generic of Topiclo 60 ml Lotion

Clobetasol Propionate scalp solution is used to treat recalcitrant corticosteroid-responsive dermatoses of the scalp, such as recalcitrant psoriasis and seborrheic dermatitis.

Pharmacology of Topiclo 60 ml Lotion

Clobetasol Propionate is a topical corticosteroid with a high potency. It works as an anti-inflammatory, anti-pruritic, and vasoconstrictor. It inhibits late-phase allergic reactions by exhibiting anti-inflammatory effect through different pathways. Mast cell density, chemotaxis, and eosinophil activation are all reduced. It also inhibits arachidonic acid metabolism and decreases cytokine production.

Dosage & Administration of Topiclo 60 ml Lotion

Clobetasol Propionate spray: Apply required quantity of spray of once or twice daily to the affected areas of the scalp and gently rub in. The total dose applied should not exceed 50 ml weekly. If necessary, Clobetasol Propionate scalp solution may be massaged into the scalp using the tips of the fingers. Therapy should be discontinued if no response is noted after one week or as soon as the lesion heals. It is advisable to use Clobetasol Propionate scalp solution for brief periods only.

Clobetasol Propionate shampoo: It should be applied to the dry (not wet) scalp once a day to the affected areas only. It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing. Treatment should be limited to 4 consecutive weeks. Total dosage of shampoo should not exceed 50 g per week. Under 18 years this preparation is not recommended.

Scalp Solution: Apply required quantity of spray of Clobetasol Scalp Solution once or twice daily to the affected areas of the scalp and gently rub in. The total dose applied should not exceed 50 ml weekly. If necessary, Clobetasol Scalp Solution may be massaged into the scalp using the tips of the fingers. Therapy should be discontinued if no response is noted after one week or as soon as the lesion heals. It is advisable to use Clobetasol Scalp Solution for brief periods only.

Contraindications

Scalp infections are a type of infection that occurs on the scalp.
Intolerance to the preparation.
In children under the age of one year, use is not recommended for dermatoses.

Side Effects of Topiclo 60 ml Lotion

As with other corticosteroids, prolonged use in large quantities or treatment of broad areas can result in enough systemic absorption to cause hypercortisolism. This impact is more likely in infants and youngsters, as well as when occlusive bandages are utilized. After a long period of treatment, local atrophy may ensue. In rare cases, corticosteroid treatment for psoriasis (or its discontinuation) is suspected to have triggered the pustular form of the illness. If symptoms of hypersensitivity emerge while using Clobetasol Propionate Scalp Solution, discontinue use immediately.

Pregnancy & Lactation

Corticosteroids used topically to pregnant animals can cause foetal development problems. Although the applicability of this discovery to humans has yet to be determined, topical steroids should not be used extensively in pregnancy, i.e. in significant dosages for lengthy periods of time. Clobetasol Propionate has not been proven to be safe during lactation.

Precautions & Warnings

It’s important to keep the preparation out of your eyes. Adrenal suppression can occur even without blockage, hence long-term continuous therapy with Clobetasol Propionate scalp solution should be avoided wherever feasible, especially in infants and toddlers. Rebound relapses, tolerance development, the danger of generalized pustular psoriasis, and the development of local or systemic toxicity due to reduced skin barrier function are all potential risks of topical corticosteroids in psoriasis. When treating psoriasis, it’s critical to keep a close eye on the patient.Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions which have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents. Bacterial infection is encouraged by the warm, moist conditions induced by occlusive dressings, and so the skin should be cleansed before a fresh dressing is applied.

Therapeutic Class

Other Topical corticosteroids

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Do not become paralyzed. Keep out of children’s reach.

Pharmaceutical Name of Topiclo 60 ml Lotion

Eskayef Pharmaceuticals Ltd

Generic of Topiclo 60 ml Lotion

Clobetasol Propionate