Topiclo 10MG


Topiclo 10MG


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Clobetasol Propionate is used to treat the following dermatoses in adults, the elderly, and children over the age of one year.

Recalcitrant dermatoses Lichen planus Discoid lupus erythematosus Other skin disorders that do not react well to less strong steroids Psoriasis (excluding broad plaque psoriasis) Recalcitrant dermatoses Lichen planus Discoid lupus erythematosus.

Pharmacology of Topiclo 10 Cream

Clobetasol Propionate is a topical corticosteroid with high potency. It works as an anti-inflammatory, anti-pruritic, and vasoconstrictor. It inhibits late-phase allergic reactions by exhibiting anti-inflammatory effects through different pathways. Mast cell density, chemotaxis, and eosinophil activation are all reduced. It also inhibits arachidonic acid metabolism and decreases cytokine production.

Dosage & Administration of Topiclo 10 Cream

Adults, elderly, and children over 1 year: Apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily and rub in gently and completely. Repeated short courses of Clobetasol Propionate may be used to control exacerbations. In more resistant lesions, especially where there is hyperkeratosis, the effect of Clobetasol can be enhanced, if necessary, by occluding the treatment area with polythene film. Overnight occlusion only is usually adequate to bring about a satisfactory response. Clobetasol Propionate is a super-high potency topical corticosteroid; therefore, treatment should be limited to 2 consecutive weeks. The maximum weekly dose should not be exceeded 50 gm/week. In the case of children, courses should be limited if possible to five days and reviewed weekly.

Cutaneous is the route of administration. Creams are particularly well suited to wet or moist surfaces. Ointments are especially useful for lesions that are dry, lichenified, or scaly.

Interaction of Topiclo 10 Cream

Corticosteroid metabolism has been demonstrated to be inhibited by co-administered medications that inhibit CYP3A4 (e.g., ritonavir, itraconazole), resulting in increased systemic exposure.


It is not recommended for patients who have a hypersensitivity to any of the preparation’s ingredients. Rosacea, acne vulgaris, perioral dermatitis, perianal and vaginal pruritus, pruritus without inflammation, and untreated skin diseases are all contraindications.

Side Effects of Topiclo 10 Cream

Burning and stinging sensations are the most commonly reported adverse effects. Itching, skin atrophy, cracking, and fissuring of the skin are less common side responses. Long-term usage of topical Clobetasol Propionate formulations has been linked to Cushing syndrome in both children and adults.

Pregnancy & Lactation

The use of Clobetasol Propionate cream in pregnant women has yielded mixed results. Corticosteroids used topically on pregnant animals can cause fetal development problems. The applicability of this discovery to people has yet to be determined. Clobetasol Propionate Cream should only be used during pregnancy and lactation if the predicted benefit outweighs the risks. to the mother outweighs the treatment’s potential hazards.

Precautions & Warnings

When using occlusive dressings, the skin should be cleaned before applying a new dressing. In psoriasis, topical corticosteroids should be administered with caution since they can cause rebound relapses and local or systemic toxicity due to reduced skin barrier function. Treatment should be limited to 5 days if applied to the face. When using Clobetasol Propionate on eyelids, be careful not to get it in your eyes, as this might cause cataracts and glaucoma.

Therapeutic Class

Other corticosteroids for topical use.

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Do not allow yourself to become frozen. Keep out of children’s reach.

Pharmaceutical Name of Topiclo 10 Cream

Eskayef Pharmaceuticals Ltd

Generic of Topiclo 10 Cream

Clobetasol Propionate