Indications

It is indicated for the treatment of fungal skin infections such as sweat rash or athlete’s foot when additional symptoms of inflammation (such as swelling, redness and itching) is present.

Pharmacology

Miconazole is a substituted imidazole that belongs to the azole family and is used to treat superficial candidiasis, dermatophytosis and pityriasis versicolor, acanthameaba, and seborrhoic dermatitis. Aspergillus spp., Cryptococcus neoformans, Pseudalescheria boydii, and some gram-positive bacteria such as Staphylococci and Streptococci are also susceptible.Hydrocortisone is a synthetic version of a naturally occurring glucocorticoid. It plays a crucial role in skin injuries such as inflammation. Antipruritic, antimycotic, and vasoconstrictive properties are also present.

Miconazole is an imidazole antifungal drug that inhibits ergosterol synthesis and thereby changes the permeability of susceptible fungi’s cell membrane. When administered to the skin, Hydrocortisone kills fungus by being absorbed into the skin cells. It works by preventing the release of specific molecules that cause inflammation. As a result, hydrocortisone helps to lessen inflammation.

Dosage & Administration

Apply to the affected area as a thin film two or four times daily for 1 to 2 weeks. Rub it well with your finger until this cream fully vanished on the skin. Treatment should be continued at least one week after the disappearance of all signs and symptoms. The same dosage applies to both adults and children.

Interaction

Miconazole’s action is inhibited by Amphotericin.

Contraindications

Individuals who are hypersensitive to it or any of its components should avoid it. Without the advice of a physician, it should not be taken in pregnant or lactating mothers.

Side Effects

Generally it is well tolerated. An allergic reaction to any of the ingredient of the cream may occur. Rarely, irritation & burning may occur.

Pregnancy & Lactation

During pregnancy and lactation, this medication should be used only when clearly needed.

Precautions & Warnings

It should be used with caution when applied to extensive surface areas or under occlusive dressings including baby napkins. Application to the face should be avoided.

Therapeutic Class

Hydrocortisone & Combined preparations

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children’s reach.

Generic

Miconazole Nitrate + Hydrocortisone

Pharmaceutical Name

Incepta Pharmaceuticals Ltd.