Indications of Tenoren Plus

Atenolol & Chlorthalidoneis combination is indicated for the treatment of hypertension.

Pharmacology of Tenoren Plus

Without membrane stabilizing or intrinsic sympathomimetic (partial agonist) properties, atenolol is a beta1-selective (cardioselective) beta-adrenergic receptor blocking medication. However, at greater doses, Atenolol blocks beta-2-adrenoreceptors, which are mostly found in the bronchial and vascular musculature, resulting in a selective effect. Chlorthalidone

Chlorthalidone is a monosulfonamyl double ring system that varies chemically from thiazide diuretics in that it contains a double ring system. It’s an oral diuretic that works for a long time and has a low toxicity level. The drug’s diuretic effect appears within 2 hours following an oral intake. It causes diuresis, resulting in increased salt and chloride excretion. Chlorthalidone has a diuretic effect that is similar to that of equivalent maximal therapeutic doses of benzothiadiazole diuretics at therapeutic doses. The cortical diluting segment of the ascending limb of Henle’s loop of the nephron appears to be the location of the action.

Dosage & Administration

Chlorthalidone is usually given at a dose of 25 mg daily; the usual initial dose of Atenolol is 50 mg daily. Therefore, the initial dose should be one Chlorthalidone 25 & Atenolol 50 mg once a day. If an optimal response is not achieved, the dosage should be increased to one Chlorthalidone 25 & Atenolol 100 mg once a day. A dose of two tablets once daily should not be used as initial therapy in elderly patients.

Interaction of Tenoren Plus

The combination of atenolol and chlorthalidone may enhance the effects of other antihypertensives like clonidine and diltiazem. Inhibitors of prostaglandin synthase, such as Indomethacin, may reduce the hypotensive effects of beta-blockers. Due to the significant risk of Lithium toxicity, this pill should not be used with Lithium.

Contraindications

In hypersensitivity to this product or sulfonamide-derived medications, the combination of atenolol and chlorthalidone is contraindicated. It’s also not recommended for people who have sinus bradycardia, first-degree heart block, cardiogenic shock, overt cardiac failure, or anuria.

Side Effects of Tenoren Plus

Atenolol and Chlorthalidone combination is usually well tolerated. Most adverse effects have been mild and transient. However, dizziness, fatigue, vertigo, nausea, diarrhea, and bradycardia have been reported rarely.

Pregnancy & Lactation

D is the pregnancy category. The combination of atenolol and chlorthalidone can harm a developing newborn and may present in breast milk. As a result, it should be avoided during pregnancy and nursing.

Precautions & Warnings

Patients with severe renal impairment, uncontrolled cardiac failure, impaired hepatic function, or liver disease should use Atenolol and Chlorthalidone with caution.

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Store in a cool and dry place, protected from light.

Pharmaceutical Name of Tenoren Plus

ACI Limited

Generic of Tenoren Plus

Atenolol + Chlorthalidone