Description
Indications of Tenoren 100
Tenoren 100 is indicated- In the administration of hypertension. It may be utilized alone or concomitantly with other antihypertensive specialists, especially with a thiazide-type diuretic. For the long-term administration of patients with angina pectoris. In the administration of hemodynamically steady patients with defnite or suspected intense myocardial localized necrosis to decrease cardiovascular mortality.
Pharmacology of Tenoren 100
The union of atenolol brought about from endeavors to deliver a β-adrenoceptor adversary that would competitively piece β1 (cardiac) receptors but have no impact on β2-receptors. It is classified as a β1 particular (cardioselective) β-adrenergic receptor adversary with no membranestability action and no fractional agonist action. It is particularly the foremost hydrophilic of the as of now accessible β- blockers and hence enters the lipid of cell films ineffectively.
Dosage & Administration
Hypertension: The initial dose of Atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. The full effect of this dose will usually be seen within one to two weeks. If an optimal response is not achieved, the dosage should be increased to Atenolol 100 mg given as one tablet a day. Increasing the dosage beyond 100 mg a day is unlikely to produce any further benefit.
Angina Pectoris: The initial dose of Atenolol is 50 mg given as one tablet a day. If an optimal response is not achieved within one week, the dosage should be increased to Atenolol 100 mg given as one tablet a day. Some patients may require a dosage of 200 mg once a day for optimal effect. Twenty-four hour control with once daily dosing is achieved by giving doses larger than necessary to achieve an immediate maximum effect. The maximum early effect on exercise tolerance occurs with doses of 50 to 100 mg, but at these doses the effect at 24 hours is attenuated, averaging about 50% to 75% of that observed with once a day oral doses of 200 mg.
Acute Myocardial Infarction: In patients with definite or suspected acute myocardial infarction, treatment with Atenolol I.V. Injection should be initiated as soon as possible after the patient’s arrival in the hospital and after eligibility is established. Treatment should begin with the intravenous administration of 5 mg Atenolol over 5 minutes followed by another 5 mg intravenous injection 10 minutes later. In patients who tolerate the full intravenous dose (10 mg), Atenolol Tablets 50 mg should be initiated 10 minutes after the last intravenous dose followed by another 50 mg oral dose 12 hours later. Thereafter, Atenolol can be given orally either 100 mg once daily or 50 mg twice a day for a further 6-9 days or until discharge from the hospital. If bradycardia or hypotension requiring treatment or any other untoward effects occur, Atenolol should be discontinued.
Interaction of Tenoren 100
Catecholamine-depleting drugs (eg, reserpine) may have an added substance impact when given with beta-blocking specialists. Patients treated with Atenolol also a catecholamine depletor ought to subsequently be closely watched for prove of hypotension and/or checked bradycardia which may deliver vertigo, syncope, or postural hypotension. Calcium channel blockers may too have an added substance impact when given with Atenolol. Disopyramide could be a Sort I antiarrhythmic sedate with strong negative inotropic and chronotropic impacts. Disopyramide has been related with serious bradycardia, asystole and heart disappointment when managed with beta blockers. Amiodarone is an antiarrhythmic operator with negative chronotropic properties that will be added substance to those seen with beta blockers. Beta blockers may worsen the bounce back hypertension which can take after the withdrawal of clonidine. In the event that the two drugs are coadministered, the beta blocker ought to be pulled back a few days some time recently the continuous withdrawal of clonidine.Concomitant utilize of prostaglandin synthase repressing drugs, eg, indomethacin, may diminish the hypotensive impacts of beta blockers. While taking beta blockers, patients with a history of anaphylactic response to a assortment of allergens may have a more serious response on rehashed challenge, either coincidental, symptomatic or restorative. Such patients may be inert to the regular dosages of epinephrine utilized to treat the unfavorably susceptible reaction. Both digitalis glycosides and beta-blockers moderate atrioventricular conduction and diminish heart rate. Concomitant utilize can increment the hazard of bradycardia.
Contraindications
Atenolol is contraindicated in- Sinus bradycardia, heart piece more noteworthy than to begin with degree, cardiogenic stun, and unmistakable cardiac failure. Those patients with a history of touchiness to the atenolol or any of the medicate product’s components.
Side Effect of Tenoren 100
In a arrangement of examinations within the treatment of intense myocardial dead tissue, bradycardia and hypotension happened more commonly, as anticipated for any beta blocker. In expansion, a assortment of antagonistic efects has been detailed with other beta-adrenergic blocking operators, and may be considered potential antagonistic efects of Atenolol. Hematologic: Agranulocytosis. Allergic: Fever, combined with hurting and sore throat, laryngospasm, and respiratory distress. Central Anxious Framework: Reversible mental misery advancing to catatonia; an intense reversible disorder characterized by confusion of time and put; brief term memory misfortune; enthusiastic lability with somewhat clouded sensorium; and, diminished execution on neuropsychometrics. Gastrointestinal: Mesenteric blood vessel thrombosis, ischemic colitis. Miscellaneous: There have been reports of skin rashes and/or dry eyes related with the utilize of beta-adrenergic blocking drugs. Discontinuance of the sedate ought to be considered on the off chance that any such respond
Pregnancy & Lactation
Pregnancy Category D. Caution ought to be worked out when Atenolol is managed to a nursing lady. Clinically critical bradycardia has been detailed in breast-fed newborn children. Untimely newborn children, or newborn children with disabled renal work, may be more likely to create unfavorable impacts.
Precautions & Warnings
Common: Patients as of now on a beta blocker must be assessed carefully some time recently Atenolol is managed. Beginning and consequent Atenolol measurements can be balanced descending depending on clinical perceptions counting beat and blood weight. Atenolol may exasperate fringe blood vessel circulatory disorders. Impaired Renal Work: The medicate ought to be utilized with caution in patients with impeded renal function. Geriatric Use: Hypertension and Angina Pectoris: Due to Coronary Atherosclerosis: Dosage choice for an elderly quiet ought to be cautious, more often than not beginning at the moo conclusion of the dosing run, reflecting the more prominent recurrence of diminished hepatic, renal, or cardiac work, and of concomitant illness or other medicate therapy. Acute Myocardial Localized necrosis: Measurements determination for an elderly quiet ought to be cautious, more often than not beginning at the moo conclusion of the dosing extend, reflecting more prominent recurrence of diminished hepatic, renal, or cardiac work, and of concomitant malady.
Therapeutic Class
Beta-adrenoceptor blocking drugs, Beta-blockers
Storage Conditions
Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.
Pharmaceutical Name of Tenoren 100
ACI Limited
