Indications of Tenocab 50 Tablet

This is indicated in-

• Patients with essential hypertension
• Patients with angina pectoris & hypertension as co-existing diseases
• ln post Ml patients
• ln patients with refractory angina pectoris where nitrate therapy has failed.

Pharmacology of Tenocab 50 Tablet

This is an Amlodipine and Atenolol fixed-dose combo. Inhibits calcium influx into vascular smooth muscle and cardiac muscle; has a stronger effect on vascular smooth muscle than on cardiac muscle; is a dihydropyridine calcium antagonist Amlodipine is a peripheral vasodilator that reduces peripheral vascular resistance and blood pressure by acting directly on vascular smooth muscle. Afterload is reduced by amlodipine, which lowers cardiac demand by lowering the tone, coronary vasoreactivity, and coronary vasoreactivity.

Cardioselective beta-blocker Atenolol is a beta-blocker. There is a dose-dependent cardio-selectivity. It lowers blood pressure via reducing cardiac output, plasma renin activity, and sympathetic outflow from the central nervous system (CNS). The negative inotropic and chronotropic effects of atenolol also cause a reduction in myocardial oxygen demand.

Tenocab 50 Tablet Dosage & Administration

Adult: This therapy is initiated with a single dose of this preparation depending upon the therapeutic response, titration of the dosage is recommended.

In elderly patients: It is advisable to initiate the therapy with ½ tablet of a fixed-dose combination of Amlodipine & Atenolol, i.e., 2.5 mg of Amlodipine & 25 mg Atenolol.

Interaction of Tenocab 50 Tablet

This medication decreases the clearance of this drug by 20% There is a possibility that the heart will be subjected to detrimental inotropic effects that are cumulative.

In doses of 1 gram and above, ampicillin may lower Atenolol concentrations.

There may be a link between beta-blockers and oral antidiabetics. In contrast, atenolol has less potential for these effects.

Contraindications of Tenocab 50 Tablet

Cardiogenic shock, hypotension, congestive heart failure, and poor left ventricular function are all symptoms of hypersensitivity to either component.

Tenocab 50 Tablet Side Effects

Tenocab 50 Tablet are well tolerated together. Anxiety or despair are some of the more common side effects.

Pregnancy & Lactation

Precautions & Warnings

With regard to patients with airway blockage, this combination should be utilized with caution.

Patients with renal impairment can benefit from the combo. As a result of a probable reduction in the excretion of unaltered Atenolol, care is advised if your creatinine clearance is less than 30 ml/min.

Due to the fact that Amlodipine’s elimination half-life is prolonged in individuals with severe liver damage, caution should be used when using the combination.

When it comes to drug withdrawal, patients should be reminded that coronary heart disease can develop without being identified.

Therapeutic Class

Combined antihypertensive preparations

Storage Conditions

Pharmaceutical Name of Tenocab 50 Tablet

ACI Limited

Generic

Amlodipine and Atenolol