Telazine 5mg

105410027000102

Telazine 5mg

3.00৳ 

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Description

Generic

Trifluoperazine

 

Indications

Excessive anxiety, tension, and agitation are all symptoms of neuroses or somatic conditions. Treatment or prevention of nausea and vomiting caused by a variety of factors. Psychotic disorders such as acute or chronic catatonic, hebephrenic, and paranoid schizophrenia, as well as psychosis caused by organic brain damage, toxic psychosis, and the manic phase of manic-depressive illness, are all treated.

 

Pharmacology

Trifluoperazine is a phenothiazine, which means it has a lot of pharmacodynamic effects that have to do with its therapeutic actions and side effects. The antagonism of dopamine receptors in the CNS is phenothiazines’ most notable action. The antipsychotic action is thought to be based on this action in the limbic system and associated areas of the cerebral cortex.

 

Dosage & Administration

Schizophrenia and other psychoses:

  • Adults and child over 12 years: Recommended starting dose is 2-5 mg b.i.d, increased by 5 mg daily after 1 week then at interval of 3 days, according to response.
  • Children (6-12 years): Dosage should be adjusted to the weight of the child and severity of the symptoms. The starting dosage is 1 mg b.i.d. Dosage may be increased gradually until symptoms are controlled or until side effects become troublesome. While it is usually not necessary to exceed dosages of 15 mg daily.
  • Elderly: Reduce initial dose by at least half

Short-term management of severe anxiety:

  • Adult and child over 12 years: 1-2 mg b.i.d, increased if necessary to 6 mg daily.
  • Child (3-5 years): 1 mg daily
  • Child (6-12 years): Up to 4 mg daily in divided dose.
  • Elderly: Reduce initial dose by at least half

Antiemetic:

  • Adult: 2-4 mg daily in divided doses; max. 6 mg daily;
  • Child 3-5 years: up to 1 mg daily, 6-12 years up to 4 mg daily.

 

Interaction

Oral anticoagulants may be less effective if you take trifluoperazine. When propranolol and trifluoperazine are taken together, their plasma levels of both drugs rise. When phenothiazines and guanethidine are used together, the antihypertensive effects of guanethidine and related compounds may be countered. When antipsychotic drugs are combined with CNS depressants like alcohol, potentiation can occur.

 

Contraindications

Trifluoperazine should not be used in patients who are comatose, have blood dyscrasias, or have known liver damage, or who are hypersensitive to the active ingredient or related compounds.

 

Side Effects

Transient restlessness, dystonias, or symptoms that resemble parkinsonism are common side effects. Drowsiness, dizziness, fatigue, blurred vision, and seizures are some of the other CNS reactions. These would not be possible without them. Peripheral oedema, blood dyscrasias, and jaundice are all possible side effects. Only very rarely have tachycardia, constipation, urinary hesitancy and retention, and hyperpyrexia been reported.

 

Pregnancy & Lactation

The safety of trifluoperazine during pregnancy has yet to be determined. As a result, it is not recommended that the drug be given to pregnant patients unless it is absolutely necessary in the opinion of the physician. The potential benefits must clearly outweigh any potential risks. Long-term jaundice, extrapyramidal signs, and hyperreflexia have all been reported.

 

Precautions & Warnings

When treating elderly patients, caution should be exercised, and the initial dosage should be reduced. Such patients are particularly vulnerable to extrapyramidal and hypotensive effects. Patients with heart disease or arrhythmias should be treated with caution as well. Patients with angina pectoris should be cautious.

 

Therapeutic Class

Drugs containing phenothiazine

 

Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children’s reach.

 

Pharmaceutical Name

SK+F