Generic

Trifluoperazine

Indications

Anxiety states: It regulates excessive anxiety, tension, and agitation, which are common in neuroses and somatic disorders. Treatment or prevention of nausea and vomiting caused by a variety of factors. Psychotic illnesses such as acute or chronic catatonic, hebephrenic, and paranoid schizophrenia, as well as psychosis caused by organic brain injury, toxic psychosis, and the manic phase of manic-depressive illness, are all treated.

Pharmacology

Trifluoperazine is a phenothiazine, which means it has a lot of pharmacodynamic aspects that have to do with its therapeutic activities and adverse effects. The antagonism of dopamine receptors in the CNS is phenothiazines’ most prominent effect. The antipsychotic activity of phenothiazines is thought to be based on this action in the limbic system and related regions of the cerebral cortex, whereas the antiemetic effect appears to be based on this action in the medullary chemoreceptor trigger zone.

Dosage & Administration

Schizophrenia and other psychoses:

• Adults and child over 12 years: Recommended starting dose is 2-5 mg b.i.d, increased by 5 mg daily after 1 week then at interval of 3 days, according to response.
• Children (6-12 years): Dosage should be adjusted to the weight of the child and severity of the symptoms. The starting dosage is 1 mg b.i.d. Dosage may be increased gradually until symptoms are controlled or until side effects become troublesome. While it is usually not necessary to exceed dosages of 15 mg daily.
• Elderly: Reduce initial dose by at least half

Short-term management of severe anxiety:

• Adult and child over 12 years: 1-2 mg b.i.d, increased if necessary to 6 mg daily.
• Child (3-5 years): 1 mg daily
• Child (6-12 years): Up to 4 mg daily in divided dose.
• Elderly: Reduce initial dose by at least half

Antiemetic:

• Adult: 2-4 mg daily in divided doses; max. 6 mg daily;
• Child 3-5 years: up to 1 mg daily, 6-12 years up to 4 mg daily.

Interaction

Oral anticoagulants may be less effective if you use trifluoperazine. When propranolol and trifluoperazine are taken together, their plasma levels of both medications rise. When phenothiazines and guanethidine are taken together, the antihypertensive effects of guanethidine and similar drugs may be countered. When antipsychotic medications are taken with CNS depressants like alcohol, potentiation can occur. Anticonvulsants and hypnotics

Contraindications

Trifluoperazine should not be used in patients who are comatose, have blood dyscrasias, or have known liver damage, or who are hypersensitive to the active component or similar compounds.

Side Effects

Transient restlessness, dystonias, or symptoms that resemble parkinsonism are common side effects. Drowsiness, dizziness, tiredness, blurred vision, and seizures are some of the other CNS reactions. These would not be possible without them. Peripheral oedema, blood dyscrasias, and jaundice are all possible side effects. Only very infrequently have tachycardia, constipation, urine difficulty and retention, and hyperpyrexia been observed.

Pregnancy & Lactation

Trifluoperazine has not been proven to be safe during pregnancy. As a result, it is not advised that the medication be administered to pregnant women unless it is absolutely necessary in the opinion of the physician. The potential advantages must obviously outweigh any potential risks. Long-term jaundice, extrapyramidal symptoms, hyperreflexia, and hypoflexia have all been observed in newborn children whose mothers used phenothiazines.

Lactation: In the case of lactation, there is a lack of adequate human data.

Precautions & Warnings

When treating older individuals, caution should be exercised, and the starting dosage should be decreased. Such individuals are more vulnerable to extrapyramidal and hypotensive effects. Patients with heart problems or arrhythmias should be handled with prudence as well. Patients with angina pectoris should be cautious.

Therapeutic Class

Phenothiazine drugs

Storage Conditions

It should be stored between 15 and 30 degrees Celsius, away from light and moisture.

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.