Generic

Paracetamol

Indications

Paracetamol is demonstrated for fever, common cold and flu, cerebral pain, toothache, ear infection, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic torment, back torment, post-operative torment, postpartum torment, provocative torment and post immunization torment in children. It is additionally shown for rheumatic & osteoarthritic torment and solidness of joints.

Pharmacology

Paracetamol has pain relieving and antipyretic properties with powerless anti-inflammatory activity.Paracetamol (Acetaminophen) is thought to act basically within the CNS, expanding the torment limit by hindering both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 proteins included in prostaglandin (PG) synthesis.Paracetamol may be a para aminophenol subsidiary, has pain relieving and antipyretic properties with powerless anti-inflammatory movement. Paracetamol is one of the foremost broadly utilized, most secure and quick acting pain relieving. It is well endured and free from different side impacts of headache medicine.

Dosage and Administration

Tablet:

 Adult: 1-2 tablets every 4 to 6 hours up to a maximum of 4 gm (8 tablets) daily.

 Children (6-12 years): ½ to 1 tablet 3 to 4 times daily. For long term treatment it is wise not to exceed the dose beyond 2.6 gm/day.

Extended Release Tablet:

 Adults & Children over 12 years: Two tablets, swallowed whole, every 6 to 8 hours(maximum of 6 tablets in any 24 hours).The tablet must not be crushed.

Syrup/Suspension:

 Children under 3 months: 10 mg/kg body weight (reduce to 5 mg/kg if jaundiced) 3 to 4

times daily.

 3 months to below 1 year: ½ to 1 teaspoonful 3 to 4 times daily.

 1-5 years: 1 -2 teaspoonful 3 to 4 times daily.

 6-12 years: 2-A teaspoonful 3 to 4 times daily.

 Adults: 4-8 teaspoonful 3 to 4 times daily.

Suppository:

 Children 3-12 months: 60-120 mg,4 times daily.

 Children 1-5 years: 125-250 mg 4 times daily.

 Children 6-12 years: 250-500 mg 4 times daily.

 Adults & children over 12 years: 0.5-1 gm 4 times daily.

Paediatric Drop:

 Children Upto 3 months: 0.5 ml (40 mg)

 4 to 11 months: 1.0 ml (80 mg)

 7 to 2 years: 1.5 ml (120 mg). Do not exceed more than 5 dose daily for a maximum of 5 days.

Paracetamol tablet with actizorb technology: It dissolves up to five times faster than standard Paracetamol tablets. It is a fast acting and safe analgesic with marked antipyretic property. It is specially suitable for patients who, for any reason, can not tolerate aspirin or other analgesics.

 Adults and children (aged 12 years and over): Take 1 to 2 Tablets every four to six hours as needed. Do not take more than 8 caplets in 24 hours.

 Children (7 to 11 years): Take ½-1 Tablet every four to six hours as needed. Do not take more than 4 caplets in 24 hours. Not recommended in children under 7 years.

Interaction

Patients who have taken barbiturates, tricyclic antidepressants and liquor may appear decreased capacity to metabolize expansive dosages of Paracetamol. Liquor can increment the hepatotoxicity of Paracetamol overdosage. Inveterate ingestion of anticonvulsants or verbal steroid contraceptives actuate liver chemicals and may anticipate fulfillment of restorative Paracetamol levels by expanding first-pass digestion system or clearance.

Contraindications

It is contraindicated in known touchiness to Paracetamol.

Side Effects

Side impacts of paracetamol are as a rule mellow, in spite of the fact that hematological responses counting thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been detailed. Pancreatitis, skin rashes, and other unfavorably susceptible responses happen every so often.

Precautions & Warnings

Paracetamol ought to be given with caution to patients with impeded kidney or liver work. Paracetamol ought to be given with care to patients taking other drugs that influence the liver.

Pregnancy & Lactation

Pregnancy category B concurring to USFDA. This sedate ought to be utilized amid pregnancy as it were in case clearly required

Storage Conditions

Keep in a dry put absent from light and warm. Keep out of the reach of children.

Therapeutic Class

Non opioid analgesics

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.