Generic

Paracetamol

Indications

Paracetamol is demonstrated for fever, common cold and flu, cerebral pain, toothache, earache, body ache, myalgia, neuralgia, dysmenorrhoea, sprains, colic torment, back torment, post-operative pain, postpartum torment, fiery torment and post-immunization torment in children. It is additionally shown for rheumatic & osteoarthritic torment and firmness of joints.

Pharmacology

Paracetamol has pain-relieving and antipyretic properties with frail anti-inflammatory activity. Paracetamol (Acetaminophen) is thought to act essentially within the CNS, expanding the torment threshold by hindering both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 chemicals included in prostaglandin (PG) synthesis.

Paracetamol could be a para aminophenol subordinate and has pain-relieving and antipyretic properties with weak anti-inflammatory movement. Paracetamol is one of the foremost broadly utilized, most secure, and quick-acting analgesics. It is well endured and free from different side impacts of aspirin.

Dosage and Administration

Tablet:

Grown-up: 1-2 tablets each 4 to 6 hours up to a greatest of 4 gm (8 tablets) daily.

Children (6-12 a long time): ½ to 1 tablet 3 to 4 times every day. For long-term treatment, it is astute not to surpass the measurements past 2.6 gm/day.

Expanded Discharge Tablet:

Grown-ups & Children over 12 a long time: Two tablets, gulped in entirety, each 6 to 8 hours (maximum of 6 tablets in any 24 hours). The tablet must not be pulverized.

Syrup/Suspension:

Children beneath 3 months: 10 mg/kg body weight (decrease to 5 mg/kg on the off chance that embittered) 3 to 4 times daily.

3 months to underneath 1 year: ½ to 1 teaspoonful 3 to 4 times daily.

1-5 a long time: 1 -2 teaspoonfuls 3 to 4 times daily.

6-12 a long time: 2-A teaspoonfuls 3 to 4 times daily.

Grown-ups: 4-8 teaspoonfuls 3 to 4 times day by day

Suppository:

Children 3-12 months: 60-120 mg,4 times daily.

Children 1-5 a long time: 125-250 mg 4 times daily.

Children 6-12 a long time: 250-500 mg 4 times daily.

Grown-ups & children over 12 a long time: 0.5-1 gm 4 times daily.

Pediatric Drop:

Children Upto 3 months: 0.5 ml (40 mg)

4 to 11 months: 1.0 ml (80 mg)

7 to 2 a long time: 1.5 ml (120 mg). Don’t surpass more than 5 dosage day by day for the greatest of 5 days.

Paracetamol tablet with actors innovation: It breaks down up to five times speedier than standard Paracetamol tablets. It could be a quick-acting and secure pain relieving with checked antipyretic properties. It is especially appropriate for patients who, for any reason, can not endure headache medicine or other analgesics.

Adults and children (matured 12 a long time and over): Take 1 to 2 Tablets every four to six hours as required. Don’t take more than 8 caplets in 24 hours.

Children (7 to 11 a long time): Take ½-1 Tablet each for four to six hours as required. Don’t take more than 4 caplets in 24 hours. Not suggested in children under 7 for a long time.

Interaction

Patients who have taken barbiturates, tricyclic antidepressants, and liquor may appear diminished ability to metabolize expansive measurements of Paracetamol. Liquor can increment the hepatotoxicity of Paracetamol overdosage. Unremitting ingestion of anticonvulsants or verbal steroid contraceptives induces liver proteins and may anticipate the fulfillment of restorative Paracetamol levels by expanding first-pass metabolism or clearance.

Contraindications

It is contraindicated in known touchiness to Paracetamol

Side Effects

Side impacts of paracetamol are as a rule gentle, in spite of the fact that hematological responses including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other unfavorably susceptible responses happen once in a while.

Pregnancy & Lactation

Pregnancy category B concurs with USFDA. This sedate ought to be utilized amid pregnancy as it were if clearly needed

Precautions & Warnings

Paracetamol ought to be given with caution to patients with impeded kidney or liver function. Paracetamol ought to be given with care to patients taking other drugs that influence the liver

Therapeutic Class

Non opioid analgesics

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children

Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.