T-Mycin 5ML


T-Mycin 5ML


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Tobramycin is a topical antibiotic used to treat external bacterial infections of the eye caused by bacteria that are susceptible to it. as an example,

  • Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus spp. of group A beta-hemolytic and nonhemolytic species are Gram-positive bacteria.
  • E.coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Haemophilus influenzae, Morganella morganii, Acinetobacter calcoaceticus, Providentia, Serratia, Salmonella spp., and certain Neisseria spp. Gram-negative bacteria: E.coli



Tobramycin’s bactericidal action is taken up into susceptible bacterial cells via an active transport pathway, similar to other aminoglycosides. Tobramycin binds to the 30s and, to a lesser extent, the 50s subunits of the bacterial ribosome within the cell, blocking protein synthesis and causing transcription mistakes.The manner in which cell death is brought about is imperfectly understood, and other mechanisms may contribute, including effects on membrane permeability.


Dosage & Administration

Ophthalmic ointment:

  • In mild to moderate infection, apply a small amount 2-3 times daily into the conjunctival sac(s).
  • In severe cases of infection, apply a small amount 3-4 times daily into the conjunctival sac(s) until improvement is obtained, then reduce the dose gradually.

Ophthalmic solution:

  • In mild to moderate infections: Instill 1or 2 drops into the affected eye(s) every 4 hours.
  • In severe infections: Instill 2 drops into the affected eye(s) every hour until improvement is observed.

Pediatric use: Safety and effectiveness in children below the age of 1 year have not been established.



Tobramycin should be used with caution in patients who are taking other medicines that contain neuromauscular blocking agents or are ototoxic.



It is not recommended for people who are hypersensitive to Tobramycin or any of the preparation’s constituents.


Side Effects

Localized ocular toxicity, conjunctival erythema, hypersensitivity, including lid itching and swelling are the most common side effects of Tobramycin ophthalmic solution.


Pregnancy & Lactation

Pregnancy Classification B. In pregnant women, there are no sufficient and well-controlled trials. Only use this medication during pregnancy if the potential advantages outweigh the danger to the fetus. It is possible that the drug will be excreted in human milk. It must be decided whether to stop nursing or to take the medication.


Precautions & Warnings

Some people may experience minor sensitivity to aminoglycosides administered topically. If you have a sensitive reaction, stop using it. Long-term use may cause non-susceptible organisms and fungus to overgrow.


Therapeutic Class

Ophthalmic antibacterial drugs


Storage Conditions

Keep away from light and store in a cool (below 25°C) and dry location. Keep out of children’s reach. Within 4 weeks of first opening, use.


Pharmaceutical Name

Aristopharma Ltd.