Generic

Tobramycin

Indications

For the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany its use.

Pharmacology

Tobramycin is a member of aminoglycosides, which shows bactericidal activity by inhibiting normal protein synthesis of bacteria.

Dosage & Administration

Eye Drops: In mild to moderate disease, 1 drop into the affected eye(s) every 4 hours. In severe infections, 1 drop into the affected eye(s) hourly until improvement, following which dosage should be reduced prior to discontinuation.

Eye Ointment: In mild to moderate disease it should be applied thinly and evenly into the conjunctival sac of the affected eyes 2 to 3 times per day. For severe cases it should be applied thinly and evenly into the conjunctival sac of the affected eyes 3 to 4 times per day. Following improvement, treatment should be reduced prior to discontinuation.

Interaction

Tobramycin should be used with caution in patients who are taking other medicines that contain neuromauscular blocking agents or are ototoxic.

Contraindications

Patients with known hypersensitivity to any of its components.

Side Effects

The most frequent side effects of Tobramycin are localized ocular toxicity and hypersensitivity, including lid itching and swelling and conjunctival erythema.

Pregnancy & Lactation

Pregnancy Classification B. In pregnant women, there are no sufficient and well-controlled trials. Only use this medication during pregnancy if the potential advantages outweigh the danger to the fetus. It is possible that the drug will be excreted in human milk. It must be decided whether to stop nursing or to take the medication.

Precautions & Warnings

As with other antibiotic preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If super-infection or drug resistance occurs, or irritation or sensitization to any of the components of this preparation develops, treatment should be discontinued and appropriate therapy should be initiated. The patient should be advised to consult a physician if improvement fails to occur, or if signs of super-infection occur.

Therapeutic Class

Ophthalmic antibacterial drugs

Storage Conditions

Keep away from light and store in a cool (below 25°C) and dry location. Keep out of children’s reach. Within 4 weeks of first opening, use.

Pharmaceutical Name

Aristopharma Ltd.