Solivo 500 MG


Solivo 500 MG


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Naproxen Sodium + Esomeprazole Magnesium



Naproxen & Esomeprazole is demonstrated for the help of signs & indications of-

  • Osteoarthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis &
  • To diminish the chance of creating gastric ulcers in patients at hazard of creating NSAID-associated gastric ulcers.



This comprises of an prompt discharge Esomeprazole Magnesium layer & an enteric-coated Naproxen center. As a result, Esomeprazole is discharged to begin with into the stomach, earlier to the disintegration of Naproxen within the small intestine.

Naproxen could be a NSAID with pain relieving & antipyretic properties. The instrument of action of Naproxen is to hinder the prostaglandin union. Esomeprazole could be a proton pump inhibitor that stifles gastric corrosive discharge by particular restraint of the H+/k+ -ATPase within the gastric parietal cell by acting particularly on the proton pump, Esomeprazole pieces the ultimate step in corrosive generationin this way diminishing gastric corrosiveness.



Carefully consider the potential benefits & dangers of this tablet & other treatment choices some time recently choosing to utilize this tablet. Utilize the most reduced compelling dosage for the most brief term reliable with person understanding treatment objectivesIn the event that a dosage of Esomeprazole lower than a add up to every day measurements of 40 mg is more suitable, a distinctive treatment ought to be considered.

Rheumatoid Joint pain, Osteoarthritis and Ankylosing Spondylitis-

  • Adults: One tablet twice every day of either: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
Juvenile Idiopathic Joint pain in Pre-adult Patients 12 year of Age & Older-
  • Weight more prominent than 50 kg: 375 mg naproxen/20 mg of esomeprazole; or 500 mg naproxen/20 mg of esomeprazole
  • Weight 38 kg to less than 50 kg: One tablet twice day by day of 375 mg naproxen/20 mg of esomeprazole.



Don’t part, chew, smash or break up the tablet. This tablet is to be taken at slightest 30 minutes some time recently dinners.



With medicine: 

  • Concomitant utilize of NSAIDs may decrease the antihypertensive impact of Pro inhibitors, diuretics & beta-blockers
  • Concomitant utilize of this tablet and warfarin may result in an expanded chance of a dying complication.
  • Esomeprazole represses gastric corrosive discharge & may meddled with the retention of drugs where gastric pH is an vital determinant of bioavailability (eg. Ketoconazole, press salts and digoxin).
With nourishment & others: Organization of Naproxen & Esomeprazole along with high-fat nourishment in solid volunteers does not influence the degree of assimilation of naproxen but altogether drags out tmax by 10 hours and diminishes crest plasma concentration (Cmax) by almost 12%



  • Known extreme touchiness to any component of this tablet or substituted benzimidazoles.
  • History of asthmay urticaria or other allergic-type responses after taking ibuprofen or other NSAIDs.
  • Use amid the peri-operative period within the setting of coronary course bypass unite (CABG) surgery.


Side Effects

In common, this planning is well enduredThe foremost common unfavorable responses in clinical trials (>5%): erosive gastritis, dyspepsia, gastritis, the runs, gastric ulcer, upper stomach tormentsickness etc.


Pregnancy & Lactation

Pregnancy category C. In late pregnancy, it ought to be dodged since it may cause untimely closure of the ductus arteriosus. This tablet ought to not be utilized in nursing moms due to the Naproxen component.


Precautions & Warnings

Patients with known CV disease/risk components may be at more noteworthy hazard. This tablet ought to be utilized with caution in patients with liquid maintenance or heart disappointment.

Therapeutic Class

Drugs for Osteoarthritis, Drugs utilized for Rheumatoid Joint pain, Non-steroidal Anti-inflammatory Drugs (NSAIDs)


Storage Conditions

Store at temperature of underneath 30°C, secure from light & dampness. Keep out of reach of children.


Pharmaceutical Name

Healthcare Pharmaceuticals Ltd.