Indications

Bronchospasm: Salbutamol Inhaler is used to treat or prevent bronchospasm in people with bronchial asthma, as well as reversible airway obstruction in people with bronchitis and emphysema.

Exercise-Induced Bronchospasm: Salbutamol Inhaler can be used to treat acute dyspnea and can also be used as a preventative measure before exercising or to prevent exercise-induced asthma.

Pharmacology

Salbutamol is a selective agonist of the 2-adrenoceptor. It works on the 2-adrenoceptors of bronchial smooth muscle at therapeutic levels but has little or no effect on the 1-adrenoceptors of cardiac muscle. In reversible airway blockage, salbutamol produces short-acting (4-6 hours) bronchodilation with a rapid onset (within 5 minutes). It also inhibits the release of bronchoconstrictor mediators such as histamine, neutrophil chemotactic factor (NCF), and prostaglandin D2 via acting as an anti-inflammatory on mast cells.

Dosage & Administration

Administer Salbutamol Inhaler by oral inhalation only. Shake Salbutamol Inhaler well before each spray.

For relief of acute episodes of bronchospasm:

• Adults: 1 or 2 puffs as necessary. The maximum dose is up to 8 puffs in 24 hours.
• Children: Half the adult dose.

To prevent allergen-or exercise-induced bronchospasm:

• Adults: 2 puffs 15 minutes prior to exercise or exposure to the allergen. The maximum dose is 2 puffs, up to 4 times a day.
• Children: Half the adult dose.

Chronic therapy:

• Adults: Up to 200 mcg (2 puffs) four times daily.
• Children: Up to 200 mcg (2 puffs) four times daily.

Interaction

Salbutamol and non-selective beta-blockers like propranolol should not be prescribed simultaneously in most cases. 2-agonist treatment has the potential to cause significant hypokalemia. Concomitant treatment with xanthine derivatives, steroids, diuretics, and hypoxia may intensify this impact, therefore use caution if you have acute severe asthma. In such cases, it is advised that serum potassium levels be monitored.

Contraindications

Patients having a history of hypersensitivity to salbutamol or any other component of a Salbutamol inhaler should avoid using it.

Side Effects

Salbutamol is easily tolerated by most people. During inhalation, just a few adverse effects have been recorded. Tremors, anxiety, muscle cramps, headache, palpitation, a compensatory small increase in heart rate, cardiac arrhythmias (including atrial fibrillation, supraventricular tachycardia, and extrasystoles), and tachycardia are all possible symptoms. Salbutamol inhalation can cause mouth and throat discomfort.

Pregnancy & Lactation

Pregnancy Classification C. In pregnant women, there are no sufficient and well-controlled studies using salbutamol inhalers or salbutamol sulfate. During pregnancy, this inhaler should only be used if the possible benefit outweighs the potential risk to the fetus. The components of the Salbutamol inhaler are not known to be excreted in human milk. When administering this inhaler to a nursing mother, exercise caution.

Precautions & Warnings

Paradoxical Bronchospasm: Inhaled salbutamol sulfate can cause life-threatening paradoxical bronchospasm. If paradoxical bronchospasm occurs, the Salbutamol inhaler should be stopped right away and another treatment plan implemented. When it comes to inhaled formulations, it’s important to remember that paradoxical bronchospasm frequently develops after the first use of a new canister.

Cardiovascular Impacts: Salbutamol inhaler, like all other β2-adrenergic agonists, can create clinically critical cardiovascular impacts in a few patients such as changes in beat rate or blood weight. On the off chance that such impacts happen, the Salbutamol inhaler may be suspended. In expansion, beta-agonists have been detailed to deliver electrocardiogram (ECG) changes, such as smoothing of the T wave, prolongation of the QTc interim, and ST-segment discouragement. The clinical significance of these discoveries is obscure. In this manner, the Salbutamol inhaler, like all other sympathomimetic amines, ought to be utilized with caution in patients with fundamental cardiovascular clutters, particularly coronary lacking, cardiac arrhythmias, and hypertension.

Therapeutic Class

Short-acting selective & β2-adrenoceptor stimulants.

Storage Conditions

A canister that has been pressurized. Even if the container appears to be empty, do not puncture, damage, or burn it. Keep out of direct sunshine and extreme heat. Keep it below 30°C. Do not allow yourself to become frozen. Keep your distance from the eyes. Keep your distance from youngsters. Only on or by a licensed physician’s prescription will it be dispensed.

Generic

Salbutamol

Pharmaceutical Name

ACME Laboratories Ltd.