Description
Indications of S-Citapram 5 Tablet
Escitalopram Oxalate is indicated in the-
- Treatment of major depressive episodes.
- Treatment of panic disorder with or without agoraphobia.
- Treatment of social anxiety disorder (social phobia).
- Treatment of generalized anxiety disorder.
- Treatment of obsessive-compulsive disorder.
Pharmacology of S-Citapram 5 Tablet
Escitalopram is a selective serotonin reuptake inhibitor that is used orally (SSRI). The pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram is escitalopram. When it comes to inhibiting 5-HT reuptake, escitalopram is at least 100 times more effective than the R-enantiomer. Escitalopram has no or poor affinity for serotonergic and other receptors, such as alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic, and benzodiazepine receptors.
Dosage & Administration of S-Citapram 5 Tablet
The safety of daily doses more than 20 mg has not been established. Escitalopram Oxalate comes in a single daily dose that can be taken with or without food.
The usual dose for major depressive episodes is 10 mg once a day. The dose may be increased to a maximum of 20 mg per day depending on the individual patient’s reaction. To get an antidepressant response, it usually takes 2-4 weeks. Treatment for at least 6 months after the symptoms have subsided is essential to consolidate the response.
Panic disorder with or without agoraphobia: For the first week, a dose of 5 mg is recommended before increasing to 10 mg daily. Depending on the patient’s response, the dose can be adjusted up to a maximum of 20 mg per day. After around 3 months, the maximum effectiveness is obtained. The treatment takes several months to complete.
The first dosage for generalized anxiety disorder is 10 mg once daily. The dose may be increased to a maximum of 20 mg per day depending on the individual patient’s reaction. Patients receiving 20 mg/day for at least 6 months were examined for long-term therapy of responders. At regular intervals, the treatment benefits and dose should be re-evaluated.
Interaction of S-Citapram 5 Tablet
Antidepressants such as SSRIs and related antidepressants should not be begun for at least two weeks after quitting an MAOI. An MAOI, on the other hand, should not be taken until at least one week after an SSRI or similar antidepressant has been discontinued (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine).
Contraindications
Escitalopram is not recommended for patients who have a known hypersensitivity to Escitalopram, Citalopram, or any of the drug’s inactive components. It’s not a good idea to take escitalopram and monoamine oxidase/pimozide at the same time.
Side Effects of S-Citapram 5 Tablet
SSRIs are less sedating than tricyclic antidepressants and have fewer antimuscarinic and cardiotoxic effects. GGI effects (nausea, vomiting, dyspepsia, abdominal pain, diarrhoea, constipation), anorexia with weight loss (increased appetite and weight gain have also been reported), and hypersensitivity reactions (rash, urticaria, angioedema, anaphylaxis, arthralgia, myalgia, and photosensitivity) are all common SSRI side effects.
Pregnancy & Lactation
The hazards and advantages of treating a pregnant woman with Escitalopram throughout the third trimester should be carefully considered by the physician. It’s passed through human breast milk. The risk of citalopram exposure for the newborn and the benefits of Escitalopram medication for the mother should be considered when deciding whether to continue or stop nursing or Escitalopram therapy.
Precautions & Warnings
SSRIs should be used with caution in patients with epilepsy (avoid if poorly controlled, discontinue if convulsions develop), concurrent electroconvulsive therapy (prolonged seizures have been reported with fluoxetine), history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase bleeding risk, history of bleeding disorders (especially gastro-intestinal bleeding).
Therapeutic Class
SSRIs & related anti-depressant drugs
Storage Conditions
Do not store at temperatures above 30°C. Keep out of children’s reach.
Pharmaceutical Name of S-Citapram 5 Tablet
General Pharmaceuticals Ltd
