Rostatin 10 MG


Rostatin 10 MG


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Rosuvastatin is demonstrated in-

  • Heterozygous Hypercholesterolemia (Familial and Non familial)
  • Homozygous Hypercholesterolemia (Familial)
  • Mixed Dyslipidemia (Fredrickson Sort IIa and IIb)
  • Primary anticipation of cardiovascular infection



Rosuvastatin may be a particular and competitive inhibitor of HMG-CoA reductase, the rate-limiting chemical that changes over 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a forerunner of cholesterol. Rosuvastatin produces its lipid-modifying impacts in two ways. To begin with, it increments the number of hepatic LDL receptors on the cell surface to upgrade take-up and catabolism of LDL. Moment, Rosuvastatin inhibits hepatic union of VLDL, which diminishes the full number of VLDL and LDL particles.



Dosage run: 5-40 mg once every dayUtilize 40 mg measurements as it were for patients not coming to LDL-C objective with 20 mg

HoFH: Beginning measurements 20 mg/day.
Pediatric patients with HeFH: 5-10 mg/day for patients 8 to less than 10 a long time age, and 5-20 mg/day for patients 10 to 17 a long time of age.
Pediatric patients with HoFH: 20 mg/day for patients 7 to 17 a long time of age.


Rosuvastatin can be taken with or without nourishment, at any time of day.



Exceptional sedate intuitive of Rosuvastatin are-

  • Cyclosporine: Combination increments Rosuvastatin introduction. Rosuvastatin dosage ought to be constrained to 5 mg once daily.
  • Gemfibrosil: Combination ought to be dodgedIn case utilized together, Rosuvastatin dosage ought to be restricted to 10 mg once daily.
  • Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increments Rosuvastatin presentation. Rosuvastatin dosage ought to be to 10 mg once day by day.
  • Coumarin anticoagulants: Combination draws out universal normalized proportion (INR). Steady INR ought to be accomplished earlier to beginning Rosuvastatin. INR ought to be checked regularly until steady upon start or change of Rosuvastatin therapy.
  • Concomitant lipid-lowering treatments: Utilize with fibrates and niacin items may increment the hazard of skeletal muscle impacts.



Rosuvastatin is contraindicated if-

  • Known extreme touchiness to item components
  • Liver illness, which may incorporate unexplained determined rises in hepatic transaminase levels
  • Pregnant ladies and ladies who may gotten to be pregnant
  • Nursing moms


Side Effects

Rosuvastatin is for the most part well enduredThe foremost visit antagonistic occasions thought to be related to Rosuvastatin were cerebral pain, myalgia, clogging, asthenia, stomach torment and sickness.


Pregnancy & Lactation

The security in pregnant ladies has not been set up. It isn’t known whether Rosuvastatin is excreted in human drain or not.


Precautions & Warnings

Skeletal muscle impacts (e.g., myopathy and rhabdomyolysis): Dangers increment with utilize of 40 mg dosageprogressed age (>65 year), hypothyroidism, renal impedance and combination utilize with cyclosporine, lopinavir/ritonavir, atazanavir/ritonavir or certain other lipid-lowering drugs. Patients ought to be prompted to expeditiously report unexplained muscle tormentdelicacy or shortcoming. Rosuvastatin can be ceased on the off chance that signs or indications show up.
Liver protein variations from the norm and checkingDiligent rises in hepatic transaminases can occur.

Liver chemicals ought to be checked some time recently and amid treatment

Therapeutic Class

Other Anti-anginal & Anti-ischaemic drugs, Statins


Storage Conditions

Keep underneath 30oC temperature, ensured from light & dampness. Keep out of the reach of children.


Pharmaceutical Name

Drug International Ltd.