Rivarox 15MG


Rivarox 15MG


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Rivaroxaban 2.5 mg: For the anticipation of atherothrombotic occasions in grown-up patients after an Intense Coronary Disorder (ACS) with lifted cardiac biomarkers (Troponin or CK-MB). It is co-administered with Headache medicine alone or with Ibuprofen additionally Clopidogrel orTidopidine. Rivaroxaban 10-20 mg: To diminish the hazard of stroke and systemic embolism in patients with nonvalvular atrial fibrillation Deep vein thrombosis (DVT) & pneumonic embolism (PE) and decrease within the hazard of repeat of DVT and of PE For the prophylaxis of DVT, which may lead to PE in patients experiencing knee or hip substitution surgery.



Rivaroxaban may be a exceedingly particular coordinate calculate Xa inhibitor. Restraint of figure Xa hinders the inherent and outward pathway of the blood coagulation cascade, hinders thrombin arrangement. Rivaroxaban does not restrain thrombin (enacted figure II) and no impacts on platelets have been illustrated.


Administration & Dosage

Rivaroxaban 2.5 mg:

  • The recommended dose: 2.5 mg twice daily. Patients should also take a daily dose of 75-100 mg Aspirin or a daily dose of 75-100 mg Aspirin in addition to either a daily dose of 75 mg clopidogrel or a standard daily dose of ticlopidine.

Rivaroxaban 10-20 mg:

  • Nonvalvular Atrial Fibrillation: For patients with Creatinin Clearance >50 mL/min: 20 mg orally, once daily with the evening meal. For patients with Creatinin Clearance 15-50 ml/min: 15 mg orally, once daily with the evening meal.
  • Treatment of DVT & PE: 15 mg orally twice daily with food for the first 21 days for the initial treatment of acute DVT or PE. After the initial treatment period, 20 mg orally once daily with food for the remaining treatment.
  • Prevention in the risk of recurrence of DVT and of PE: 20 mg once daily with food.
  • Prophylaxis of DVT following Hip replacement surgery: 10 mg once daily for 35 days.
  • Prophylaxis of DVT following knee replacement surgery: 10 mg once daily for 12 days.

May be taken with or without food.



Antidepressants such as SSRIs and related antidepressants should not be started for at least two weeks after stopping an MAOI. An MAOI, on the other hand, should not be started until at least one week after an SSRI or similar antidepressant has been discontinued (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine).



Concomitant utilize with drugs that are combined P-gp and CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin, erythromycin, fluconazole, diltiazem, verapamil, dronedarone) increments in Rivaroxaban introduction and pharmacodynamic impacts (i.e., figure Xa restraint and PT prolongation), that’s why ought to be maintained a strategic distance from. Co-administration of Rivaroxaban with a combined P-gp and solid CYP3A4 inducer (e.g., rifampicin, phenytoin, carbamazepine) diminishes the viability of Rivaroxaban conjointly ought to be dodged. The concomitant utilize of other drugs like anti-platelet operators, heparin, fibrinolytic treatment, NSAIDs may cause an expanded hazard of dying.


Side Effect

It is contraindicated in patients with known touchiness of Rivaroxaban or any of the excipients of the item. It is additionally contraindicated in patients with dynamic neurotic dying.


Pregnancy & Lactation

Rivaroxaban could be a pregnancy category C sedate. There are no satisfactory or well-controlled considers of Rivaroxaban in pregnant ladies, and dosing for pregnant women has not been built up. It isn’t known in the event that Rivaroxaban is excreted in human drain. The security and adequacy of Rivaroxaban has not been built up in breastfeeding ladies.


Precautions & Warnings

Early suspension of Rivaroxaban, within the nonappearance of satisfactory elective anticoagulation increments the hazard of thrombotic occasions. Rivaroxaban increments the chance of dying that can be deadly in nearness of taking after hazard variables– dying clutters, uncontrolled serious blood vessel hypertension, gastrointestinal malady (e.g., fiery bowel illness, oesophagitis, gastritis and gastroesophageal reflux malady), vascular retinopathy, bronchiectasis, history of aspiratory dying. Signs or indications of neurological impedance ought to be observed in case of neuraxial anesthesia (spinal/epidural anesthesia) or spinal cut as epidural or spinal hematoma can happen. Rivaroxaban isn’t suggested in patients with pneumonic embolism who display with hemodynamic precariousness or who may get thrombolysis or aspiratory embolectomy.


Therapeutic Class

Oral Anti-coagulants


Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.


Pharmaceutical Name

Eskayef Pharmaceuticals Ltd.