Indications of Ridon 10 mg Tablet

• Delayed stomach emptying, gastroesophageal reflux, and esophagitis are all symptoms of dyspeptic symptom complex.
• Upper abdominal discomfort, sensation of abdominal distension, and epigastric fullness.
• Eructation, flatulence, and early satiety are all symptoms of early satiety.
• Vomiting and nausea.
• Regurgitation of stomach contents into the mouth, with or without heartburn.
• Dyspepsia without ulcers.
• Acute nausea and vomiting of functional, organic, infectious, or dietetic origin, as well as nausea and vomiting produced by radiation or pharmacological therapy, and nausea and vomiting induced in migraine.
• Dopamine agonist-induced nausea and vomiting in Parkinson’s disease.
• Increasing the speed of barium transit in follow-up radiological examinations.

Pharmaceutical Name of Ridon

Eskayef Pharmaceuticals Ltd.

Pharmacology

Domperidone is a dopamine agonist that works by blocking dopamine receptors in the ChemoreceptorTrigger Zone (CTZ) in the stomach. Its gastroprokinetic activity is based on the inhibition of dopamine receptors in the gastrointestinal tract, which regulate motility. Domperidone has practically little effect on dopaminergic receptors in the brain due to its poor penetration across the blood-brain barrier, therefore eliminating psychotropic and neurologic adverse effects. Domperidone restores normal upper gastrointestinal motility and tone, aids stomach emptying, improves antral and duodenal peristalsis, and controls pylorus contraction. Domperidone also reduces gastric regurgitation by increasing esophageal peristalsis and lowering esophageal sphincter pressure.

Dosage & Administration

Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring.

The usual recommended oral dose of Domperidone is as follows:

• Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
• Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptom:

• Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

• Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
• Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

• Adults (including elderly): 30-60 mg every 4-8 hours.
• Children: The maximum daily dose rectally in children’s is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
• The maximum period of treatment is 12 weeks.

Interaction of Ridon

Bromocriptine’s hypoprolactemic impact may be reduced by domperidone. Antimuscarinics and opoid analgesics may counteract Domperidone’s effect on Gl function. When domperidone is used with MAO (monoamine oxidase) inhibitors, caution should be maintained.

Contraindications

Domperidone is not recommended for individuals who have a known hypersensitivity to the medication or for newborns. When gastrointestinal stimulation is potentially hazardous, such as gastrointestinal bleeding, mechanical blockage, or perforation, do not use domperidone. Patients with a prolactin-releasing pituitary tumor are also advised against taking it (prolactinoma).

Side Effect of Ridon

Hyperprolactinemia is a side effect of domperidone (1.3 percent ). Galactorrhea, breast growth, discomfort, and a decrease in libido are all possible side effects. During domperidone therapy, dry mouth (1 percent), thirst, headache (1.2 percent), nervousness, sleepiness (0.4 percent), diarrhea (0.2 percent), skin rash, and itching (0.1 percent) are all possible side effects. Clinical investigations show that extrapyramidal responses occur in 0.05 percent of individuals.

Pregnancy & Lactation

Because the safety of domperidone has not been established, it is not advised for use during pregnancy. The teratogenic impact in the fetus has not been proven in animal research. Domperidone can help with galactorrhea and postpartum lactation. It’s released in breast milk, but in such little amounts that it’s not considered hazardous.

Precautions & Warnings

Domperidone should be used with extreme caution in children due to an elevated risk of extrapyramidal effects due to an incompletely formed blood-brain barrier in young children. Domperidone should be taken with caution in patients with hepatic impairment since it is heavily metabolized in the liver.

Therapeutic Class

Prokinetic medicines, Motility stimulants/Dopamine antagonists, Motility stimulants/Dopamine antagonists

Storage Conditions

Do not store at temperatures above 30°C. Keep out of the reach of youngsters and away from light.

Generic of Ridon 10 mg

Domperidone Maleate