Generic

Paracetamol + Caffeine

Indications

Fever, common cold, and influenza, headache, toothache, earache, bodyache, myalgia, neuralgia, dysmenorrhoea, sprains, colic pain, back pain, post-operative pain, postpartum discomfort, inflammatory pain, and post vaccination pain in children are among the conditions for which paracetamol is prescribed. It’s also used to treat rheumatic and osteoarthritic pain, as well as joint stiffness.

Pharmacology

Dosage & Administration

Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.

Child dose: Not recommended for children below 12 years.

Interaction

Patients taking barbiturates, tricyclic antidepressants, and alcohol may have a reduced ability to metabolize large doses of paracetamol. Alcohol can increase liver toxicity from acetaminophen overdose. Long-term use of oral contraceptives or steroidal contraceptives can induce liver enzymes and may prevent therapeutic levels of paracetamol from being achieved by increasing metabolism or first-pass clearance.

Contraindications

In individuals with significant renal function impairment and hepatic disorders, paracetamol is contraindicated (Viral Hepatitis).

Side Effects

Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leucopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally

Pregnancy & Lactation

Pregnancy category B according to USFDA. This drug should be used during pregnancy only if clearly needed

Precautions & Warnings

Paracetamol should be given with caution to patients with impaired kidney or liver function. Paracetamol should be given with care to patients taking other drugs that affect the liver.

Therapeutic Class

Non-opioid analgesics

Storage Conditions

Store in a dry place away from light and heat. Keep out of reach of children. Opioid analgesics

Pharmaceuticals name

Opsonin Pharma Ltd.