Generic

Vitamin A

Indications

Vitamin A deficiency in ophthalmology, such as night blindness, dry eye, and dermatology, such as skin, hair, and nail changes. Concomitant treatment of mucosal diseases such as sinusitis, bronchitis, acne vulgaris, ichthyosis, Darryl disease, and psoriasis. Meet the growing demand for vitamin A, anti-infection and night blindness. It has also been shown to compensate for vitamin A deficiency after diarrhea and measles prevention.

Pharmacology

Beta-carotene, retinol, and the retina have effective and reliable vitamin A activity. Retinaldehyde and retinol are in a state of chemical equilibrium in the body and have equivalent anti-dry eye activity. The retina and opsin combine to form rhodopsin in the retina, which is necessary for dark adaptation.
Vitamin A prevents growth retardation and maintains the integrity of epithelial cells. Normal adult liver storage is sufficient to meet the two-year vitamin A requirement. Vitamin A is easily absorbed from the gastrointestinal tract. In the gastrointestinal tract, β-carotene biosynthesizes vitamin A. Absorption of vitamin A requires bile salts, pancrelipase, and dietary fats. It is transported in the blood to the liver through the chylomicron part of the lymph. Vitamin A is stored primarily in the Kupffer cells of the liver in the form of palmitate. Normal serum vitamin A is 80,300 units per 100 ml (plasma range is 3070 micrograms per deciliter) and carotenoids are 270,753 units per 100 ml. The normal adult liver contains about 100 to 300 micrograms / g, mainly retinol palmitate.

Dosage & Administration

For Adults: 50000 IU-100000 IU daily up to 200000 IU if necessary.

Children (Above 1 year):

• Night blindness, Bitot’s spots, Xerophthalmia: 200000 IU 1st day, 2nd day, 14th day
• Measles: 200000 IU 1st day, 2nd day
• Diarrhea, Respiratory tract infection: 200000 IU every time after disease
• Severe malnutrition: 200000 IU single-dose or as directed by the registered physician.

Contraindications

Hypervitaminosis of vitamin A. Sensitivity to any of the ingredients in this preparation.

Side Effects

Vitamin A poisoning includes irritability, vomiting, loss of appetite, headache, dry and itchy skin, skin peeling, fatigue, ankle and foot pain, myalgia, body hair loss, papilledema, nystagmus, liver cirrhosis, and cirrhosis of the liver.

Pregnancy

Currently, the safety of consuming more than 6,000 units of vitamin A per day during pregnancy has not been determined. Taking more than the recommended daily intake of vitamin A to pregnant women can cause fetal harm. Animal reproduction studies have shown fetal abnormalities associated with overdose in several species. Record abnormalities of the central nervous system, eyes, upper jaw, and urogenital tract. Vitamin A exceeding the recommended daily amount is contraindicated in women who are pregnant or may become pregnant. If vitamin A is used during pregnancy, or the patient becomes pregnant while taking vitamin A, the patient should be informed of the potential danger to the fetus. The recommended dietary allowance (RDA) (5,000 units) for vitamin A recommended by the United States is recommended for breastfeeding mothers.

Precautions

Ensure that there is no vitamin A interval after long-term vitamin A treatment. Do not take more than 5000 IU daily during pregnancy. Vitamin A doses greater than 50,000 IU should only be under medical supervision.

Therapeutic Class

Vitamin-A preparations.

Storage Conditions

Keep below  25°C temperature, away from light & moisture.  Keep out of the reach of children.

Pharmaceutical Name

Drug International Ltd.