Generic

Indications

Sodium Vaiproate oral is indicated for the treatment of all types of epilepsy, e.g.

• Partial seizures
• Absence seizures (petit mal)
• Generalized tonic-clonic seizures (grand mal)
• Myoclonic seizures
• Atonic seizures
• Mixed seizures that include absence attack
• Prophylaxis of febrile convulsion
• Prophylaxis of post-traumatic epilepsy.

It is also indicated in the treatment of bipolar disorder & prophylaxis of migraine.

Pharmacology

Sodium Valproate, the dynamic fixing of this planning is invested with anti-epileptic action against a assortment of seizures. The instrument by which Sodium Valproate applies its anti-epileptic impacts has not been built up. Be that as it may, it has been recommended that its movement is related to extend brain levels of gamma-aminobutyric corrosive (GABA).

Dosage & Administration

Sodium Valproate tablets may be given once or twice daily. Sodium Valproate syrup should be given in divided doses.

Epilepsy-

• Adults: Initially 600 mg daily given in 2 divided doses, preferably after food, increasing by 200 mg/day at 3-day intervals to a maximum of 2.5 g daily in divided doses until control of seizure is achieved. Usual maintenance dose is 1-2 g daily (20-30 mg/kg daily)
• Children (up to 20 kg): Initially 20 mg/kg daily in divided doses, may be increased provided plasma concentrations monitored (above 40 mg/kg daily also monitor clinical chemistry and hematological parameters).
• Children (over 20 kg): Initially 400 mg daily in divided doses increased until control (usually in the range of 20-30 mg/kg daily) Maximum 35 mg/kg daily.

Febrile convulsion: 20-30 mg/kg/day in 3 divided doses.

Bipolar disorder: Initially 20-30 mg/kg/day in 2-3 divided doses; adjust dosage in 3-5 days. Maintenance dosage is 1000-2000 mg/day.

Prophylaxis of migraine: 300 mg twice daily, although some may require 1000 mg daily.

Interaction

Sodium Vaiproate appears to act as a non specific inhibitor of drug metabolism. Drugs to which it interacts most significantly are Phenobarbital, Phenytoin, Warfarin, Aspirin etc.

Contraindications

Sodium Valproate is contraindicated to patients who have known touchiness to the medicate and liver brokenness. Utilize of Sodium Valproate is confined amid pregnancy and in ladies of childbearing potential.

Side Effects

The foremost common side impacts are anorexia, sickness and heaving. In any case, these side impacts are minimized with the utilize of enteric coated tablets. Impacts on the CNS incorporate sedation, ataxia and tremor. These indications happen rarely and more often than not react to a diminish in dosages. Hasty, alopecia and incitement of craving have been watched sometimes. Sodium Vaiproate has a few impacts on hepatic work of which rise of liver chemicals in plasma is watched in up to 40% of patients and often occurs asymptomatically amid the primary few months of treatment. Once in a while a explode hepatitis that will be lethal may create. Children underneath 2 a long time of age with other restorative conditions and those being treated with different antiepileptic operators are extraordinarily inclined to endure from hepatic harm, intense pancreatitis and hyperammonemia have too been as often as possible related with the utilize of Sodium Valproate.

Pregnancy & Lactation

Sodium Vaiproate crosses the placenta and in people, introduction to valproate within the to begin with trimester has been related with neural tube absconds such as anencephaly and spina bifida in infant. Pregnant ladies treated with Sodium Vaiproate ought to be advertised to assess serum a-fetoprotein. Sodium Valproate is excreted in breast miik. In any case, breast-feeding by a mother taking Sodium Valproate likely causes no chance to the child.

Precautions & Warnings

In patients with epilepsy (avoid if poorly controlled, discontinue if convulsions develop), concurrent electroconvulsive therapy (prolonged seizures reported with fluoxetine), history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase bleeding risk, and history of bleeding disorders, SSRIs should be used with caution.

Therapeutic Class

Primary anti-epileptic drugs

Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.

Pharmaceutical Name