Generic

Losartan Potassium

Indications

Hypertension:

• Losartan potassium is suitable for the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs (such as thiazide diuretics).
• Renal protection in patients with type 2 diabetic proteinuria:
• Losartan potassium is used to delay the progression of renal disease in patients with type 2 hypertension diabetic proteinuria, defined as the ratio of urine albumin to creatinine> 300 mg/g.

Pharmacology

Losartan potassium is the first orally active non-peptide angiotensin II receptor blocker. Binds to AT1 receptors found in many tissues, including vascular smooth muscle, adrenal glands, kidneys, and heart, and reduces several important biological effects, including vasoconstriction and the release of aldosterone that causes high blood pressure.

Dosage & Administration

For most patients, the usual starting and maintenance dose is 50 mg per day. If the antihypertensive effect of 50 mg once a day is insufficient, it is recommended to take 25 mg twice a day before increasing the dose. For patients with insufficient intravascular volume (for example, patients receiving high-dose diuretics), a starting dose of 25 mg once a day should be considered. Losartan potassium can be taken once or twice a day. The total daily dose ranges from 25 mg to 100 mg.

Interaction

Rifampicin and fluconazole can reduce the level of the active metabolite of potassium losartan. Simultaneous use of Losartan Potassium and Hydrochlorothiazide may enhance the antihypertensive effect. Concurrent use of potassium-sparing diuretics (such as spironolactone, triamterene, amiloride), potassium supplements, or potassium-containing salt substitutes may lead to increased serum potassium. The antihypertensive effect of losartan may be weakened by the non-steroidal anti-inflammatory drug indomethacin. Simultaneous use of ACE inhibitors, angiotensin receptor antagonists, anti-inflammatory drugs, and thiazide diuretics can increase the risk of renal failure.

Contraindications

Pregnant women and patients who are allergic to any component of this product should not use Losartan potassium. Patients with diabetes should not combine losartan potassium with aliskiren.

Side Effects

The side effects of using Losartan potassium are mild and short-lived. The most common side effects are dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection. Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis.

Pregnancy & Lactation

Pregnancy category D. Taking Losartan potassium in the second or third trimester of pregnancy will increase the risk to the fetus. It is not clear whether losartan potassium will be excreted from human milk, because many drugs are excreted from human milk and because it may have adverse effects on infants, a decision must be made to discontinue breast-feeding or to stop taking the drug. medicine, taking into account that the drug is effective The importance of mothers.

Precautions & Warnings

The use of Losartan potassium in the second and third trimesters of pregnancy reduces fetal kidney function and increases fetal and neonatal morbidity and mortality. For patients with insufficient intravascular volume (for example, patients treated with high-dose diuretics), symptomatic hypotension may occur. The plasma concentration of losartan potassium in patients with liver cirrhosis is significantly increased. Changes in renal function have been reported in patients with renal insufficiency, including renal insufficiency.

Therapeutic Class

Angiotensin III receptor blocker

Storage Conditions

Store in a dry place, away from light and heat. Keep out of the reach of children.

Pharmaceutical Name

Beximco Pharmaceuticals Ltd.