Probis Plus 2.5/6.25 MG


Probis Plus 2.5/6.25 MG


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Indications of Probis Plus 2.5/6.25 Tablet

Bisoprolol is used to treat hypertension and angina.

Heart failure ranging from mild to severe


Pharmacology of Probis Plus 2.5/6.25 Tablet

The most selective ß1 blocker is Bisoprolol Hemifumarate. It has the highest affinity for the ß1 receptor of any beta-blocker currently on the market. Blocks the ß1 adrenergic receptor in the heart and vascular smooth muscle, lowering heart rate and cardiac output and lowering arterial blood pressure. In patients with non-ß1 selective ß1-blockers, ß-blockers can impact lipid metabolism, however Bisoprolol does not produce any changes in the cholesterol fraction, including the cardioprotective HDL-cholesterol, over long-term medication.


Dosage and Administration of Probis Plus 2.5/6.25 Tablet

Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg. In clinical trials of Bisoprolol/Hydrochlorothiazide combination therapy using Bisoprolol doses of 2.5 to 20 mg and Hydrochlorothiazide doses of 6.25 to 25 mg, the antihypertensive effects increased with increasing doses of either component.

Initial Therapy: Antihypertensive therapy may be initiated with the lowest dose of this conbination, one 2.5/6.25 mg tablet once daily. Subsequent titration (14 day intervals) may be carried out with this tablets up to the maximum recommended dose 20/12.5 mg once daily, as appropriate.

Replacement Therapy: The combination may be substituted for the titrated individual components.

Therapy Guided by Clinical Effect: A patient whose blood pressure is not adequately controlled with 2.5-20 mg Bisoprolol daily may instead be given this conbination. Patients whose blood pressures are adequately controlled with 50 mg of hydrochlorothiazide daily, but who experience significant potassium loss with this regimen, may achieve similar blood pressure control without electrolyte disturbance if they are switched to this conbination.


Interaction of Probis Plus 2.5/6.25 Tablet

This combination medicine may enhance the effects of other antihypertensive medications used at the same time. Other beta-blocking medications should not be taken with this combo therapy. Patients using catecholamine-depleting medicines like reserpine or guanethidine should be constantly watched because Bisoprolol Fumarate’s additional beta-adrenergic blocking action may cause an excessive reduction in sympathetic activity. If clonidine therapy is to be stopped, it is recommended that this combo medicine be stopped for many days before the clonidine is stopped. When cardiac depressants or inhibitors of AV conduction, such as calcium antagonists (especially of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes) or antiarrhythmic medicines, such as disopyramide, are administered concurrently, this combination medication should be used with caution. Beta-blockers and digitalis glycosides both delay atrioventricular conduction and lower heart rate. Concurrent use can put you at risk for bradycardia.



Cardiogenic shock, overt heart failure, second or third degree AV block, significant sinus bradycardia, anuria, and hypersensitivity to any component of this product or other sulfonamide-derived medications are all contraindications.


Side effects of Probis Plus 2.5/6.25 Tablet

In general, it is well tolerated. The majority of side effects have been minor and short-lived. Fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest discomfort, palpitations, rhythm abnormalities, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis, etc. are some of the side symptoms that may occur.


Pregnancy & Lactation

Pregnancy Category C (Use During Pregnancy). In pregnant women, there are no sufficient and well-controlled trials. Only if the possible benefit outweighs the risk to the fetus should Bisoprolol Fumarate and Hydrochlorothiazide be used during pregnancy.

Bisoprolol Fumarate has not been investigated in nursing women, either alone or in conjunction with Hydrochlorothiazide. Human breast milk contains thiazides, which are expelled. Bisoprolol Fumarate was found in trace levels in the milk of nursing rats. Because of the risk of major adverse reactions in nursing infants, a choice should be made on whether to stop breastfeeding or stop taking the drug, with the importance of the drug to the mother taken into account.


Precautions & Warnings

Certain people on thiazide diuretics may develop hyperuricemia or severe gout. Dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular tiredness, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting are all warning indications or symptoms of fluid and electrolyte imbalance. Hypokalemia can occur. If you want to stop taking this combo therapy, you should do so gradually over a two-week period. Patients should be closely monitored.


Therapeutic Class

Combined antihypertensive preparations


Storage Conditions

Keep the temperature below 30°C and away from light and moisture. Keep out of children’s reach.


Pharmaceutical Name of Probis Plus 2.5/6.25 Tablet

ACI Limited


Generic of Probis Plus 2.5/6.25 Tablet

Bisoprolol Fumarate + Hydrochlorothiazide