Pizo-A 1.5

105910078400602

Pizo-A 1.5

7.04৳ 

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In Stock

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Description

Generic

Pizotifen

 

Indications

Pizotifen is used to treat vascular headaches of the migraine type, such as classical migraine, common migraine, and cluster headache, as a preventative measure. It is ineffective in stopping migraine attacks after they have started.

 

Pharmacology

Pizotifen works by blocking serotonin and histamine’s peripheral activities in raising cranial vascular membrane permeability and plasmakinin transudation, as well as changing pain thresholds in migraines. Pizotifen inhibits serotonin signaling that causes cranial vasoconstriction, as well as serotonin-enhanced platelet activity and aggregation, by inhibiting 5-HT receptors. There is evidence that it also suppresses bradykinin’s peripheral activities. Pizotifen alters tonicity and reduces passive distension of extracranial arteries by inhibiting serotonin reuptake by blood platelets.

 

Dosage & Administration

Adults: Usually 1.5 mg daily. This may be taken as a single dose at night or in three divided doses. Dosage should be adjusted to the individual patient requirements up to a maximum of 4.5 mg daily. Up to 3 mg may be given as a single dose.

Children (aged over 2 years): Up to 1.5 mg daily, usually as a divided dose, although up to 1 mg has been given as a single dose at night.

 

Interaction

Pizotifen may enhance the central effects of sedatives, hypnotics, antihistamines (including some common cold preparations), and alcohol. The hypotensive effect of adrenergic neuron blockers is counteracted by pizotifen.

 

Contraindications

Patients who have a known hypersensitivity to any of the components in pizotifen should not use it.

 

Side Effects

The most prevalent negative effects include appetite stimulation, weight gain, and tiredness.

 

Pregnancy & Lactation

The use of Pizotifen during pregnancy is unknown, however no adverse consequences have been observed. As a result, the medicine should only be used during pregnancy if the potential benefit to the mother outweighs the danger to the fetus. Pizotifen has not been proven to be safe during nursing, thus mothers should avoid taking it during breastfeeding.

 

Precautions & Warnings

Renal impairment and urinary retention should be considered. Drowsiness can impair your ability to drive a car or operate machinery. Pizotifen boosts the effects of alcohol.

 

Therapeutic Class

Anti-histamine Preparations, Other drugs for migraine

 

Storage Conditions

Keep away from light and heat in a dry location. Keep out of children’s reach.

 

Pharmaceutical Name

ACME Laboratories Ltd.