Pizo-A 0.50 MG


Pizo-A 0.50 MG


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Pizotifen is used to treat vascular headaches of the migraine type, such as classical migraine, common migraine, and cluster headache, as a preventative measure. It is ineffective in stopping migraine attacks after they have started.



Pizotifen works by repressing the fringe activities of serotonin and histamine in expanding the film porousness of cranial vessels and transudation of plasmakinin, whereas modifying torment limits in headaches. By blocking 5-HT receptors, pizotifen constricts the flagging of serotonin in causing cranial vasoconstriction, as well as serotonin-enhanced platelet work and accumulation. There’s prove that it too hinders the fringe activities of bradykinin. Pizotifen may repress serotonin reuptake by blood platelets, which influences the tonicity and diminishes inactive distension of extracranial supply routes. The impacts of pizotifen driving to craving incitement may be due to the medicate acting at the metabolic level instead of a coordinate incitement of the craving centre.


Dosage & Administration

Adults: Usually 1.5 mg daily. This may be taken as a single dose at night or in three divided doses. Dosage should be adjusted to the individual patient requirements up to a maximum of 4.5 mg daily. Up to 3 mg may be given as a single dose.

Children (aged over 2 years): Up to 1.5 mg daily, usually as a divided dose, although up to 1 mg has been given as a single dose at night.



Pizotifen may augment the central effects of sedatives, hypnotics, antihistamines (including several common cold remedies), and alcohol. The hypotensive impact of adrenergic neuron blockers is counteracted by pizotifen.



Patients who have a known hypersensitivity to any of the components in pizotifen should not use it.


Side Effects

The most prevalent negative effects include appetite stimulation, weight gain, and tiredness.


Pregnancy & Lactation

The use of Pizotifen during pregnancy is unknown, however no adverse consequences have been observed. As a result, the medicine should only be used during pregnancy if the potential benefit to the mother outweighs the danger to the fetus. Pizotifen has not been proven to be safe during nursing, thus mothers should avoid taking it during breastfeeding.


Precautions & Warnings

Renal impairment and urinary retention should be considered. Drowsiness can impair your ability to drive a car or operate machinery. Pizotifen boosts the effects of alcohol.


Therapeutic Class

Anti-histamine Preparations, Other drugs for migraine


Storage Conditions

Keep away from light and heat in a dry location. Keep out of children’s reach.


Pharmaceutical Name

ACME Laboratories Ltd.