Permin 30 GM

105910204700401

Permin 30 GM

40.27৳ 

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In Stock

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Description

Generic

Permethrin

 

Indications

Permethrin cream is used to treat scabies and crab lice infections (lice disease). Scabies affects all members of the family. If a person is infected, all family members must be treated together.

 

Pharmacology

Permethrin cream is a topical scabicidal medication that contains Permethrin, a pyrethroid. It is used to treat infestations with Sarcoptes Scabiei (scabies). It operates on the nerve cell membrane, disrupting the sodium channel current that controls membrane polarization. The bugs’ repolarization is delayed, and they are paralyzed as a result of the perturbation.

Pharmacokinetics: The topical route is the sole permitted route of administration, and there are limited human data on systemic exposure or kinetics after permethrin application to the skin. Skin has some presystemic metabolism. During the first 48 hours, less than 0.5 percent of the permethrin applied is absorbed. Permethrin that has been absorbed is swiftly metabolized via ester hydrolysis, most likely in the liver, and the metabolites are mostly eliminated in the urine.

 

Dosage

  • Recommended duration of Treatment:
  • Adults and children over 12 years: a full tube
  • Children aged 6-12 years: up to 1⁄2 of a tube
  • Children aged 1-5 years: up to  ¼ of a tube
  • Children aged 2 months to 1 year: up to ⅛ of a tube
  • Children Less than 2 month: dose is not established
  • 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.

 

Administration

Before application of Permethrin cream the skin should be clean, cool and dry. Do not have a hot shower or bath before applying.

For adults and children over 2 years: Apply the cream to the whole body from the neck down, rubbing lightly into the skin until the cream disappears. It is important to include all skin surfaces, such as between the fingers and toes, under the nails and on the soles of the feet.

For babies under 2 years: Apply to the face, neck, ears and scalp as well, only avoiding the area immediately around the eyes and mouth.

Leave cream on for at least 8 hours, before washing off. Reapply to any area that may be washed during the 8h treatment time (such as after washing the hands). If necessary, permethrin cream should be used again after 7 days as per the advice of the doctor.

 

Interaction

Corticosteroid therapy for eczema-like reactions should be stopped before permethrin treatment because there is a risk of exacerbating scabies infection by reducing the immune response to mites.

 

Contraindications

Patients known to be allergic to pyrethroids or any component of permethrin should not use permethrin. Caregivers who use permethrin regularly can use a balloon to avoid any possible irritation to their opponents.

 

Side Effects

Among people with scabies, some people experience skin discomfort shortly after applying the cream, which is usually described as burning, stinging, or tingling. Other transient signs and symptoms of irritation include enema, edema, eczema, rash, and pyomenitis.

 

Pregnancy & Lactation

In the absence of specific studies on pregnant women, its use during pregnancy should only follow medical advice. It is not clear whether permethrin is excreted in human milk, so it should not be used by breastfeeding mothers.

 

Precautions & Warnings

Scabies infection is often accompanied by itching, edema, and erythema. Permethrin treatment can temporarily exacerbate these conditions. Patients should be advised to avoid contact with eyes during use. If the cream comes into contact with the eyes, they should be rinsed off immediately with water.

 

Therapeutic Class

Parasiticidal preparations.

 

Storage Conditions

Protect from light and moisture by storing in a cool, dry location. Keep out of children’s reach.

 

Pharmaceutical Name

ACME Laboratories Ltd.