Paridon 10 GM


Paridon 10 GM


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Indications of Paridon 10 mg Tablet

A complex of dyspeptic symptoms, usually associated with delayed gastric emptying, gastroesophageal reflux, and esophagitis:

  • Upper abdominal fullness, bloating, upper abdominal pain
  • Belching, flatulence, early satiety
  • Nausea and vomiting
  • Heartburn with or Without gastric regurgitation
  • Non-ulcer dyspepsia

Functional, organic, infectious, dietary or acute nausea and vomiting induced by radiotherapy or drug therapy or induced by migraine. Parkinson’s disease: nausea and vomiting caused by dopamine agonists. Radiological research: Accelerate barium transport in follow-up radiological research.


Pharmaceutical Name of Paridon

Drug International Ltd.



Domperidone is a dopamine antagonist that mainly blocks dopamine receptors located in the chemoreceptor activation zone (CTZ) and stomach. Its gastrointestinal motility is based on its blocking effect on dopamine receptors that affect gastrointestinal motility. Due to its weak permeability to the blood-brain barrier, domperidone has almost no effect on dopamine receptors in the brain, thus eliminating mental and neurological side effects. Domperidone restores the normal movement and tension of the upper gastrointestinal tract, promotes gastric emptying, improves gastric antrum and duodenal peristalsis, and regulates pyloric contraction. Domperidone also increases esophageal motility and reduces esophageal sphincter pressure, thereby preventing the reflux of stomach contents.


Dosage & Administration

Domperidone should be taken 15-30 minutes before meals and, if necessary, before retiring. The usual recommended oral dose of Domperidone is as follows:

  • Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily. The maximum dose of Domperidone is 80 mg daily.
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily.

In dyspeptic symptom:

  • Adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily.
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily.

In acute and sub-acute conditions (mainly in acute nausea and vomiting):

  • Adults: 20 mg (2 tablets or 20 ml suspension), every 6-8 hours daily
  • Children: 0.2-0.4 mg/kg (2-4 ml suspension/10 kg or 0.4-0.8 ml paediatric drops/10 kg) body weight, every 6-8 hours daily. (In acute nausea and vomiting maximum period of treatment is 12 weeks).

By rectum in suppositories:

  • Adults (including elderly): 30-60 mg every 4-8 hours.
  • Children: The maximum daily dose rectally in children’s is 30 mg for those weighting 10 to 25 kg. The dose may be divided throughout day if necessary.
  • The maximum period of treatment is 12 weeks.


Interactions of Paridon

Domperidone can reduce the risk of bromocriptine causing hypoprolactin effects. The effect of domperidone on GI function can be antagonized by antimuscarinic drugs and opioid analgesics. Caution should be exercised when domperidone is administered in combination with MAO (monoamine oxidase) inhibitors.



Domperidone is contraindicated in patients and newborns who are known to be allergic to this drug. Domperidone should not be used when gastrointestinal irritation may be dangerous, that is, gastrointestinal bleeding, mechanical obstruction, or perforation. Patients with prolactin-releasing pituitary tumors (prolactinomas) are also contraindicated.


Side Effects of Paridon

Domperidone can cause hyperprolactinemia (1.3%), which can cause galactorrhea, breast enlargement, pain, and loss of libido. Dry mouth (1%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), rash and itching (0.1%). In clinical studies, 0.05% of patients had extrapyramidal reactions.



The safety of domperidone has not been proven, so its use during pregnancy is not recommended. Animal studies have not shown teratogenic effects on the fetus. Domperidone can cause galactorrhea and improve postpartum lactation. It is secreted in breast milk, but the amount is very small and not enough to be considered harmful.



For children, domperidone should be used with extreme caution, because incomplete development of the blood-brain barrier can increase the risk of extrapyramidal reactions in young children. Because domperidone is highly metabolized in the liver, patients with impaired liver function should use it with caution.


Therapeutic Class

Kinetic stimulant, kinetic stimulant / dopamine antagonist, prokinetic


Storage Conditions

Store below 30°C away from light and moisture. Please keep this product out of reach of children.


Generic of Paridon

Domperidone Maleate