Ornid 500 MG


Ornid 500 MG


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Amoebiasis (intestinal and hepatic), Giardiasis, Trichomoniasis, Bacterial vaginosis, Treatment of susceptible anaerobic infections are among the conditions for which ornidazole is prescribed.



The 5-nitroimidazole derivative ornidazole is effective against protozoa and anaerobic bacteria. In sensitive species, it is reduced to reduction products that interact with DNA to destroy the helical DNA helix and strand, resulting in protein synthesis inhibition and cell death.


Dosage & Administration


  • Adults: 500 mg twice a day for 5 days.
  • Children: 10-25 mg per kg body weight in two divided doses.

Amoebic dysentery:

  • Adults: 1.5 gm once a day for 3 days.
  • Children: 40 mg per kg body weight, once a day for 3 days.


  • Adults: 1.5 gm once daily for 1-2 days.
  • Children: 40 mg per kg body weight for 2 days.

Trichomoniasis: 1.5 gm once or 500 mg twice a day for 5 days. Sexual partner should also be treated at the same time.

Bacterial vaginosis: 3 tablets of 500 mg each as a single dose or one tablet of 500 mg once daily for 5-7 days.



Ornidazole, like other imidazoles, has a minor risk of causing disulfiram-type responses. Due to a decrease in hepatic metabolism, using oral anticoagulants at the same time may increase the risk of bleeding. 5-fluorouracil clearance has been shown to be reduced by ornidazole.



Hypersensitivity to Ornidazole and other nitroimidazoles in the past. Ornidazole should not be used if you have a central nervous system disease, such as epilepsy or peripheral neuropathy.


Side Effect

The gastrointestinal tract (nausea, vomiting, epigastric discomfort) and the central nervous system have been the most common side effects of Ornidazole (dizziness, headache, lassitude). Ornidazole, unlike other nitroimidazoles, does not interact with alcohol, however this has to be investigated further.

During treatment, leukopenia has been reported on occasion. Headache, dizziness, lassitude or somnolence, tiredness, and weakness are the most common adverse central nervous system (CNS) effects of Ornidazole. Ornidazole’s adverse CNS effects may be less severe than metronidazole’s. In the trials that have been done so far, no seizures have been observed with Ornidazole.


Pregnancy & Lactation

Clinical studies that are adequate have not been done. Ornidazole should only be administered if the possible benefit outweighs the danger to the fetus or newborn.


Precautions & Warnings

Ornidazole should be used with caution in patients who have ataxia, vertigo, or mental disorientation. Blood dyscrasia, namely moderate leukopenia, has been described infrequently with long-term Ornidazole therapy. If leukopenia develops, the decision to stop treatment should be based on the severity of the illness.


Therapeutic Class

Amoebicides, Anti-diarrhoeal Antiprotozoal


Storage Conditions

Protect from light and moisture by storing at room temperature.


Pharmaceutical Name

Drug International Ltd.