Indications of Orcef DS

Cefixime is indicated in the treatment of the following infections when caused by the susceptible strains of the designated microorganisms:

• Uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis.
• Otitis Media caused by Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pyogenes.
• Pharyngitis and tonsillitis are caused by Streptococcus pyogenes.
• Acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumonia and Haemophilus influenza.
• Uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae.

Pharmaceutical Name of Orcef DS

Renata Limited

Pharmacology

Cefixime may be a third-era semisynthetic cephalosporin anti-microbial for verbal organization. It is bactericidal against a wide range of gram-positive and gram-negative microscopic organisms at effortlessly achievable plasma concentrations. It slaughters microscopic organisms by interferometer within the amalgamation of bacterial cell divider. It is exceedingly steady within the nearness of the Beta-lactamase chemical. As a result, numerous living beings safe from penicillins and a few cephalosporins due to the nearness of beta-lactamases may be helpless to Cefixime. Retention of it is almost 40% to 50% whether managed with or without nourishment.

Dosage & Administration of Orcef DS

The usual course of treatment is 7 days. This may be continued for up to 14 days depending on the severity of the infection.

Adult and children over 12 years: The recommended adult dose is 200-400 mg (1 to 2 capsules) daily, given either as a single dose or in two divided doses. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of Cefixime 400 mg is recommended.

Children (6 months or older): Usually 8 mg/kg/day given as a single dose or in two divided doses or may be given as follows

• ½-1 year: 75 mg daily.
• 1-4 years: 100 mg daily.
• 5-10 years: 200 mg daily.
• 11-12 years: 300 mg daily
• In typhoid fever, the dosage should be 10 mg/kg/day for 14 days.

Children (under 6 months): The safety and efficacy of Cefixime have not been established in children aged less than 6 months.

Interaction of Orcef DS

Carbamazepine: Concomitant utilize hoists the carbamazepine level. Warfarin and other anticoagulants: Concomitant utilizes increments of prothrombin time.

Contraindications

It is contraindicated in hypersensitivity to Cefixime or other cephalosporins.

Side Effect of Orcef DS

The sedate is by and large well endured. The foremost visit-side impacts are loose bowels and stool changes; which have been more commonly related to higher measurements. Other side impacts are sickness, stomach torment, dyspepsia, spewing, tooting, headache, and discombobulation. Hypersensitivities within the frame of hasty, pruritus, urticaria, medicate fever, and arthralgia have been detailed. These responses more often than not died down upon discontinuation of treatment.

Pregnancy & Lactation

There are, in any case, no satisfactory and well-controlled ponders in pregnant ladies. Since creature propagation ponders are not continuously prescient of human reaction, this medicate ought to be utilized amid pregnancy as it were in the case clearly required. It isn’t known that Cefixime is excreted in the human drain. So, caution ought to be worked out when Cefixime is managed by a nursing lady.

Precautions & Warnings

The medication ought to be endorsed with caution in people with a history of gastrointestinal infection, especially colitis. The medication ought to be given with caution in patients with checked impeded renal work as well as those experiencing persistent walking peritoneal dialysis and hemodialysis. Measurement alteration is as it were vital in extreme renal disappointment (creatinine clearance < 20 ml/min), in that case, a dosage of 200 mg once day by day ought to not be surpassed.

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store below 30° C in a cold, dry, and light-protected location. Keep out of children’s reach.

Generic Name of Orcef DS

Cefixime Trihydrate