Oramet SR 1 GM


Oramet SR 1 GM


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Metformin Hydrochloride



Hypersensitivity to the drug. Diabetic coma and ketoacidosis, rmparrment of renal function, chronic liver disease, cardiac failure and recent myocardial infarction.



Metformin is a biguanide oral hypoglycemic agent used to treat type 2 diabetes. It lowers basal and postprandial blood sugar. Its mechanism of action is different from that of sulfonylureas and it does not produce hypoglycemia. Metformin reduces glucose production in the liver, reduces intestinal glucose absorption, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.


Dosage & Administration

The usual starting dose is one tablet 2 or 3 times daily given during or after meals. The maximum recommended dose of metformin is 3gm daily Or as directed by the registered physician.



Combined use with carbonic anhydrase (topiramate, zonisamide) may increase the risk of lactic acidosis. Drugs that reduce the clearance of metformin (ranolazine, dotegravir, cimetidine) can increase the accumulation of metformin. Alcohol can enhance the effect of metformin on lactic acid metabolism.



Allergy to active substances or any excipients. Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis). Severe renal impairment (GFR <30 ml/min). Acute conditions that may change kidney function, such as dehydration, severe infection, shock. Acute or chronic diseases, which can cause tissue hypoxia, such as: heart or respiratory failure, recent myocardial infarction, shock, liver failure, acute alcoholism, alcoholism.


Side Effects

Oramet is normally well tolerated but sometimes gastro- intestinal disturbances may occur.



Pregnancy: Uncontrolled diabetes during pregnancy (pregnancy or permanent) is associated with an increased risk of birth defects and perinatal mortality. When the patient is planning to become pregnant and during pregnancy, it is recommended not to use metformin to treat diabetes, but to use insulin to keep blood glucose levels as close to normal as possible to reduce the risk of fetal malformations.
Breastfeeding: Metformin is secreted in breast milk. No adverse reactions were observed in breastfed newborns / infants. However, due to the limited data available, breastfeeding is not recommended during treatment with metformin. It is necessary to decide whether to stop breastfeeding, taking into account the benefits of breastfeeding and the potential risks of adverse effects on the child.



Oramet is excreted by the kidney and regular monitoring of renal function is advised Oramet in all diabetics. The use of is not advised in conditions which may cause dehydration or in patients suffering from serious infections or trauma.


Therapeutic Class



Storage Conditions

Keep the temperature below 30 ° C, protect from light and moisture. Keep out of the reach of children.


Pharmaceutical Name

Drug International Ltd.