Indications of Orabis 2.5 Tablet

Bisoprolol is used to treat hypertension and angina.

Heart failure ranging from mild to severe

Pharmacology of Orabis 2.5 Tablet

The most selective ß1 blocker is Bisoprolol Hemifumarate. It has the greatest affinity for the ß1 receptor of any beta-blocker currently on the market. Blocks the ß1 adrenergic receptor in the heart and vascular smooth muscle, lowering heart rate and cardiac output and lowering arterial blood pressure. In patients with non-ß1 selective ß1-blockers, ß-blockers can influence lipid metabolism, however Bisoprolol does not produce any changes in the cholesterol fraction, including the cardioprotective HDL-cholesterol, over long-term treatment.

Dosage & Administration of Orabis 2.5 Tablet

Hypertension: The dose of Bisoprolol must be individualized to the needs of the patient. The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose. If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily.

Angina: Usually 10 mg once daily (5 mg may be adequate in some patients) max 20 mg daily.

Heart Failure: Initially 1.25 mg once daily (in the morning) for 1 week then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then- 7.5 mg once daily for 4 weeks, then 10 mg once daily maximum 10 mg daily.

Interaction of Orabis 2.5 Tablet

Other ß-blocking medications should not be used with bisoprolol.

Contraindications

Right ventricular failure related to pulmonary hypertension and sinus bradycardia in individuals with cardiogenic shock, overt heart failure, second or third degree A-V block, and sinus bradycardia.

Side Effect of Orabis 2.5 Tablet

It is possible to have gastrointestinal problems, bradycardia, hypotension, headache, tiredness, sleep disturbances, dizziness, vertigo, thrombocytopenia, vision disturbances, and alopecia.

Pregnancy & Lactation

The most selective ß1 blocker is Bisoprolol Hemifumarate. It has the greatest affinity for the ß1 receptor of any beta-blocker currently on the market. Blocks the ß1 adrenergic receptor in the heart and vascular smooth muscle, lowering heart rate and cardiac output and lowering arterial blood pressure. In patients with non-ß1 selective ß1-blockers, ß-blockers can influence lipid metabolism, however Bisoprolol does not produce any changes in the cholesterol fraction, including the cardioprotective HDL-cholesterol, over long-term treatment.

Precautions & Warnings

During long-term bisoprolol therapy, renal, hepatic, and hematologic function should be monitored at regular intervals.

Therapeutic Class

Anti adrenergic agent (Beta blockers), Beta-adrenoceptor blocking drugs, Beta-blockers

Storage Conditions

Keep away from light and heat in a dry area. Keep out of children’s reach.

Pharmaceutical Name of Orabis 2.5 Tablet

Ibn Sina Pharmaceuticals Ltd

Generic of Orabis 2.5 Tablet

Bisoprolol Hemifumarate