Generic

Olopatadine Hydrochloride

Indications

Olopatadine is used to relieve itchiness in the eyes caused by allergic conjunctivitis.

Pharmacology

Olopatadine is a histamine H1antagonist that reduces the type 1 acute hypersensitivity reaction in vivo and in vitro, including reduction of histamine produced effects on human conjunctival epithelial cells. The alpha adrenergic, dopamine, and muscarinic type 1 and 2 receptors are all unaffected by olopatadine. Olopatadine was found to have a minimal systemic exposure after topical ocular application in humans.

Dosage & Administration

0.1% Sterile Eye Drops: One drop in each affected eye two times per day at an interval of 6 to 8 hours.

0.2% Sterile Eye Drops: One drop in the affected eye once a day.

0.7% Sterile Eye Drops: One drop in each affected eye once a day.

Interaction

May result in additive CNS depression with CNS depressants.

Contraindications

Olopatadine Hydrochloride ophthalmic solution is not recommended for people who have a known hypersensitivity to the drug.

Side Effects

Headaches have been observed to affect 7% of people. In less than 5% of patients, the following negative experiences were reported: Asthenia, blurred vision, burning or stinging, cold syndrome, dry eye, foreign body sensation, hyperemia, hypersensitivity, keratitis, lid edema, nausea, pharyngitis, pruritus, rhinitis, sinusitis, and taste perversion are all symptoms of asthenia, pharyngitis, pruritus, rhinitis, sinusitis, and taste perversion.

Pregnancy & Lactation

In pregnant women, there are no sufficient and well-controlled trials. Because animal studies do not always predict human reactions, this medicine should only be given to pregnant women if the potential benefit to the mother outweighs the risk to the fetus.

It’s unclear whether topical ocular treatment would cause enough systemic absorption to create measurable amounts in human breast milk. When administering Olopatadine Hydrochloride ophthalmic solution to a nursing mother, however, caution should be exercised.

Precautions & Warnings

Contact lens irritation should not be treated with olopatadine HCl ophthalmic solution. Soft contact lens wearers should be told to wait at least ten minutes after infusing Olopatadine Hydrochloride ophthalmic solution before putting their lenses in.

Therapeutic Class

Ophthalmic Non-Steroid drugs

Storage Conditions

Store in a dry area at a temperature of not more than 30°C. Light and dampness should be avoided. Keep out of children’s reach.

Pharmaceutical Name

Beximco Pharmaceuticals Ltd.