Olmetic Plus 20/12.5 MG


Olmetic Plus 20/12.5 MG


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Olmesartan Medoxomil & Hydrochlorothiazide



Olmetic Plus is indicated for the treatment of hypertension. This combination preparation is indicated in patients whose blood pressure is not adequately controlled on Olmesartan alone. It is not indicated for initial therapy.



Olmetic Plus is a combination preparation of Olmesartan Medoxomil and Hydrochlorothiazide, where Olmesartan is an Angiotensin II receptor antagonist (AT1 subtype), and Hydrochlorothiazide is a thiazide diuretic. Olmesartan blocks the vasoconstrictor effects of Angiotensin II by selectively blocking the binding of Angiotensin II to the AT1 receptor in vascular smooth muscle. Its action is, therefore, independent of the pathways for Angiotensin II synthesis. Hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of Hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. Co-administration of an Angiotensin II receptor antagonist (like – Olmesartan Medoxomil) tends to reverse the potassium loss associated with these diuretics (like – Hydrochlorothiazide).


Dosage & Administration

Dosage must be individualized. Olmetic Plus can be taken with or without food.


The usual recommended starting dose is one tablet of Abetis Plus® (20/12.5) once daily. Depending on the blood pressure response, the dose may be titrated at intervals of 2-4 weeks to two tablets of Abetis Plus® (40/25) once daily.

Elderly and renal impairment

In elderly patients the same dosage of the combination is recommended as for adults. No dosage adjustment is necessary in patients with mild to moderate renal impairment (Creatinine clearance is 30 ml/min, < 60 ml/min). In patients with more severe renal impairment, loop diuretics are preferred to thiazides, so Abetis Plus® is not recommended.

Children and adolescents

Olmetic Plus is not recommended for use in children below 18 years due to a lack of data on safety and efficacy.



No significant drug interactions were reported when Olmesartan was co-administered with Hydrochlorothiazide, Digoxin or Warfarin in healthy volunteers. The bioavailability of Olmesartan was not significantly altered by the co-administration of antacids [Al(OH)3/Mg(OH)2]. Olmesartan is not metabolized by the Cytochrome P450 system and has no effects on P450 enzymes; thus, interactions with drugs that inhibit, induce or are metabolized by those enzymes are not expected. Hydrochlorothiazide may cause orthostatic hypotension when administered concurrently with Alcohol, Barbiturates or Narcotics. Lithium should not generally be given with diuretics. NSAIDs can reduce the diuretic, natriuretic and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.



This combination preparation is contraindicated in patients who are hypersensitive to the active substances, to any of the excipients or to other sulfonamide-derived substances (since Hydrochlorothiazide is a sulfonamide-derived medicinal product).


Side Effects

Treatment with Olmesartan -hydrochlorothiazide was well tolerated, with an incidence of adverse events similar to placebo. Events generally were mild, transient and had no relationship to the dose of Olmesartan -hydrochlorothiazide, such as vertigo, coughing, back pain, rash, weakness, transient blurred vision, diarrhea, headache, and urinary tract infection.


Pregnancy & Lactation

Pregnancy Categories C (first trimester) and D (second and third trimesters). It is not known whether Olmesartan is excreted in human milk, but Olmesartan was excreted in the milk of lactating rats. Thiazides appear in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.


Precautions & Warnings

All patients receiving thiazide therapy should be observed for clinical signs of fluid or electrolyte imbalance: hyponatremia, hypochloremic alkalosis and hypokalemia. Hypokalemia may develop, especially with rapid diuresis, when severe cirrhosis is present, or after prolonged therapy. As a consequence of inhibiting the reninangiotensin-aldosterone system, changes in renal function may be anticipated in susceptible individuals treated with Olmesartan.


Therapeutic Class

Combined antihypertensive preparations


Storage Conditions

Protect from light and moisture by storing in a cool, dry location. Keep out of children’s reach.


Pharmaceutical Name

Drug International Ltd.