Generic

Gabapentin

Indications

Ofloxacin is suitable for the treatment of adults with mild to moderate infections caused by sensitive strains.

Lower respiratory tract: Acute bacterial exacerbation of chronic bronchitis, lung abscess, and pneumonia.

Gastrointestinal tract: intestinal fever, Shigellosis.

Multidrug-resistant tuberculosis.

Skin and skin structure: A simple infection of the skin and skin structure.

Sexually transmitted diseases: acute, uncomplicated cervical and urethral gonorrhea. Non-gonococcal urethritis and cervicitis. Mixed infection of urethra and cervix.

Urinary tract: simple urinary tract infection, complicated urinary tract infection.

Pharmacology

Ofloxacin is a synthetic 4-fluoroquinolone antibacterial agent that is effective against both Gram-negative and Gram-positive bacteria. Ofloxacin is considered to have a bactericidal action by blocking DNA gyrase, an important enzyme involved in bacterial DNA duplication, transcription, and repair.

Dosage & Administration

Intravenous (Adult):

• Skin and soft tissue infections: 400 mg bid infused over at least 1 hr.
• Complicated urinary tract infections: 200 mg daily by infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr.
• Lower respiratory tract infections, Septicaemia: 200 mg bid by infusion over at least 30 min. Max: 400 mg bid infused over at least 1 hr.

Oral (Adult):

General dosage recommendations: The dose of ofloxacin is determined by the type and severity of the infection. The dosage range for adults is 200 mg to 800 mg daily. Up to 400 mg may be given as a single dose, preferably in the morning, larger doses should be given as two divided doses. Ofloxacin tablets should be swallowed with liquid; they should not be taken within two hours of intake of magnesium/aluminium containing antacids or iron preparations since reduction of absorption of ofloxacin can occur.

• Enteric fever: For adults 200 mg, every 12 hours, for 5 days. For children 15 mg/kg/day in 2 divided doses for 3 days.
• Shigellosis: 400 mg single dose.
• Multi-drug-resistant tuberculosis: 400 mg twice daily along with conventional anti-tuberculosis drugs.
• Lower respiratory tract infection: 400 mg daily, increasing, if necessary, to 400 mg twice daily.
• Uncomplicated Urinary Tract Infections: A single dose of 200/400 mg.
• Uncomplicated urethral and cervical gonorrhoea: A single dose of 400 mg.
• Non-gonococcal urethral and cervicitis: 400 mg daily in single or divided doses.
• Complicated Urinary Tract Infection: 200/400 mg/day for 7 days.

Children: Ofloxacin is usually not indicated for use in children or growing adolescents.

Elderly: No adjustment of dosage is required in the elderly.

May be taken with or without food. Avoid antacids or supplements containing Fe or Zn within 2 hr before or after ofloxacin. Ensure adequate hydration.

Interaction

Antacids containing magnesium, aluminum, or calcium may inhibit ofloxacin absorption. Ofloxacin oral absorption may be hampered by iron or zinc.

Contraindications

In individuals who have a known hypersensitivity to 4-fluoroquinolone antibacterials, ofloxacin should be avoided. Patients with a history of epilepsy or a reduced seizure threshold should avoid it. Ofloxacin is typically avoided by children and adolescents, as well as pregnant or lactating mothers.

Side Effect

Ofloxacin is typically well tolerated and has a low risk of clinical adverse effects. Reactions of the gastrointestinal and central neurological systems are prevalent among the side effects. The gastrointestinal side effects include nausea, rash, vomiting, stomach discomfort, diarrhoea, and gastrointestinal distress. Headaches, dizziness, and sleeplessness are common central nervous system responses.

Pregnancy & Lactation

Ofloxacin’s safety during pregnancy has yet to be determined. Ofloxacin may pass into breast milk, although no evidence on this is available.

Precautions & Warnings

In individuals who have a known hypersensitivity to 4-fluoroquinolone antibacterials, ofloxacin should be avoided. Patients with a history of epilepsy or a reduced seizure threshold should avoid it. Ofloxacin is typically avoided by children and adolescents, as well as pregnant or lactating mothers.

Therapeutic Class

4-Quinolone preparations, Aural Anti-bacterial preparations

Storage Conditions

Temperatures should be kept between 15 and 30 degrees Celsius. Protect yourself from the sun.

Pharmaceutical Name

Drug International Ltd.