Nodep 20 MG


Nodep 20 MG


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Fluoxetine Hydrochloride



Fluoxetine is indicated in-

  • Depressive illness
  • Bulimia nervosa and anorexia nervosa
  • Obsessive compulsive disorders
  • Pre-menstrual syndrome



Fluoxetine Hydrochloride could be a phenylpropylamine subordinate upper for verbal organization, it is chemically irrelevant to tricyclic, tetracycline or other accessible antidepressants. Fluoxetine has been appeared to specifically hinder the reuptake of serotonin (5-HT) at the presynaptic neuronal layer which causes expanded synaptic concentration of serotonin within the CNS. This comes about in various utilitarian changes related with improved serotonergic neurotransmission. Fluoxetine shows up to have no impact on the reuptake of norepinephrine and dopamine and does not show antihistaminic or alpha1 adrenergic blocking movement at normal restorative doses.


Dosage & Administration

Initial treatment: Recent studies suggest that 20 mg/day of Fluoxetine may be sufficient to obtain satisfactory antidepressant response. Consequently, a dose of 20 mg/day administered in the morning is recommended as the initial dose.

A dose increase may be considered after several weeks if no clinical improvement is observed. Dosage above 20 mg/day, should be administered on a bid schedule (i.e. morning and noon) and should not exceed a maximum dose of 80 mg/day. As with other antidepressants, the full antidepressant effect may be delayed until 4 weeks of treatment or longer. As with many other medications, a lower or less frequent dosage should be used in patients with renal and/or hepatic impairment.

A lower or less frequent dosage should also be considered for patients, such as elderly, with concurrent disease or on multiple medication. A recommended maximum dose for elderly patients is 60 mg per day.Maintenance treatment: It is generally agreed among expert psychopharmacologists that acute episode of depression requires several months or longer sustained pharmacologic therapy. Fluoxetine is also used in dosage of 60 mg daily for the management of bulimia nervosa.



May lead to serotonin disorder with serotonergic drugs (e.g. triptans, TCAs, fentanyl, tramadol, lithium, buspirone, tryptophan). May increment hazard of dying with headache medicine, NSAIDs, warfarin and other anticoagulants. May increment plasma levels of phenytoin. Potentially Lethal: May increment hazard of serotonin disorder with concomitant admin or inside 14 days of MAOIs withdrawal. May increment the QTc drawing out impact of pimozide and thioridazine.



Fluoxetine Hydrochloride is contraindicated in patients known to be extremely touchy to it. Monoamine oxidase inhibitors: There have been reports of genuine, in some cases lethal responses (counting hyperthermia, inflexibility, myoclonus, autonomic precariousness with conceivable fast vacillations of imperative signs and changes of mental status that incorporate extraordinary tumult advancing to ridiculousness and coma) in patients getting Fluoxetine in combination with monoamine oxidase inhibitors (MAOIs), and in patients who have as of late ceased Fluoxetine and are at that point begun on MAOIs. A few cases displayed with highlights taking after neuroleptic dangerous disorder. Subsequently, Fluoxetine ought to not be utilized in combination with MAOI, or inside 14 days of ceasing treatment with MAOI. Since Fluoxetine and its major metabolites have exceptionally long disposal half-lives, at slightest 5 weeks ought to be permitted after ceasing Fluoxetine and some time recently beginning MAOI.


Side Effects

Gastrointestinal: Nausea, vomiting, dyspepsia, dry mouth, and diarrhoea.

Neurological: Anxiety, nervousness, insomnia/ drowsiness and fatigue.

Others: Excessive sweating, pruritus, skin rashes associated with liver, kidney and lung involvement. It has therefore been advised that Fluoxetine therapy should be discontinued in any patient who develops a skin rash.


Pregnancy & Lactation

The risks and benefits of treating a pregnant woman with Escitalopram during the third trimester should be carefully considered by the physician. It’s passed through human breast milk. The risk of citalopram exposure for the infant and the benefits of Escitalopram treatment should be considered when deciding whether to continue or stop nursing or Escitalopram therapy.


Precautions & Warnings

As Fluoxetine experiences hepatic digestion system and renal excretion, it ought to be utilized with caution and in diminished measurements in patients with impeded hepatic or renal work. Since of its epileptogenic impact, it ought to be utilized with caution in patients with epilepsy or a history of such clutters. Fluoxetine may modify glycaemic control and so caution is additionally justified in diabetic subjects. Discouraged patients with suicidal tendencies ought to be carefully directed amid treatment. Fluoxetine isn’t ordinarily considered a appropriate shape of treatment for the depressive component of bipolar (hyper depressive) ailment as lunacy may be accelerated.


Therapeutic Class

Phenothiazine related drugs


Storage Conditions

Protect from light and moisture by storing below 30°C. Keep the medicine out of children’s reach.


Pharmaceutical Name

General Pharmaceuticals Ltd.