Indications

Angina pectoris prevention with nitroglycerin is recommended. This form’s beginning of action is too slow to be effective in preventing an acute anginal episode.

Pharmacology

Nitroglycerin promotes vascular smooth muscle relaxation, resulting in a vasodilator action on both peripheral arteries and veins. Venous dilation promotes peripheral blood pooling and reduces venous return to the heart, lowering left ventricular end-diastolic pressure (preload), while arterial relaxation lowers systemic vascular resistance and arterial pressure (afterload).

Dosage & Administration

Dosage should always be adjusted according to the requirement and response obtained by the individual patient and the severity of the anginal pain. For adults, one Nitroglycerin 2.6 mg sustained released tablet or capsule in the morning and evening. This should be taken empty stomach.

Interaction

Nitroglycerin widens fringe blood vessels and may increment the antihypertensive properties of vasodilators, calcium adversaries, and beta-adrenergic blockers. Concomitant utilization of nitrates with tricyclic antidepressants and liquor may cause tall blood weight. Concomitant utilization of nitrates with phosphodiesterase sort 5 (PDE5) inhibitors, such as sildenafil, vardenafil, and tadalafil cause a drop in blood weight. Headache medicine diminishes the clearance and upgrades the hemodynamic impacts of nitroglycerin. Nitroglycerin may decrease the pharmacologic impacts of heparin when utilized concomitantly. Nitrates increment the bioavailability of dihydroergotamine.

Contraindications

In patients who have a known allergy to nitroglycerin, other organic nitrates, or nitrites, or to the medicine’s excipients, nitroglycerin is contraindicated. Acute myocardial infarction, severe anemia, head trauma, cerebral hemorrhage, or closed-angle glaucoma are other contraindications.

Side Effects

Headaches are common at the beginning of treatment, although they normally go away after a few days. If the headache continues, the dosage should be reduced. Tachycardia, postural hypotension, syncope, cyanosis, and methemoglobinemia are some of the other side symptoms.

Pregnancy & Lactation

Nitroglycerin should not be used during pregnancy or lactation unless your doctor says it’s very necessary.

Precautions & Warnings

In people who are prone to closed-angle glaucoma, nitroglycerin should be administered with caution. Sudden termination of medication, like with other drugs used to treat angina pectoris, might cause symptoms to worsen. When stopping a long-term medication, the dosage should be progressively reduced over several days, and the patient should be closely observed. To avoid the risks of hypotension and tachycardia, it’s important to pay close attention to hemodynamic monitoring and clinical state when using nitroglycerin in the early stages of acute myocardial infarction.

Therapeutic Class

Coronary vasodilators: nitrates.

Storage Conditions

Keep away from light and heat in a cool, dry area. All drugs should be kept out of the reach of youngsters.

Generic

Nitroglycerin

Pharmaceutical Name

Popular Pharmaceuticals Ltd.