Neugalin 50 MG

105910103302601

Neugalin 50 MG

11.03৳ 

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Description

Generic

Pregabalin

 

Indications

Pregabalin is indicated for:

  • Management of neuropathic pain associated with diabetic peripheral neuropathy
  • Management of post-herpetic neuralgia
  • Adjunctive therapy for adult patients with partial onset seizures
  • Management of fibromyalgia
  • Neuropathic pain associated with spinal cord injury.

 

Pharmacology

Pregabalin could be a basic subsidiary of the inhibitory neurotransmitter gamma-amino butyric corrosive (GABA). It does not tie specifically to GABAA, GABAB, or benzodiazepine receptor. Pregabalin ties with tall partiality to the alpha-2-delta location (an assistant subunit of voltage-gated calcium channels) in central anxious framework tissues. Verbal bioavailability of Pregabalin is ≥90% and is free of dosage. It is dispensed with from the systemic circulation basically by renal excretion as unaltered sedate with a cruel disposal half-life of 6.3 hours in subjects with ordinary renal function.

 

Dosage & Administration

Neuropathic pain associated with diabetic peripheral neuropathy: The maximum recommended dose of Pregabalin is 100 mg three times a day (300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Dosing should begin at 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability.

Post-herpetic neuralgia: The recommended dose of Pregabalin is 75 to 150 mg two times a day, or 50 to 100 mg three times a day (150 to 300 mg/day) in patients with creatinine clearance of at least 60 mL/min. Dosing should begin at 75 mg two times a day, or 50 mg three times a day (150 mg/day) and may be increased to 300 mg/day within 1 week based on efficacy and tolerability.

Adjunctive therapy for adult patients with partial onset seizures: In general, it is recommended that patients be started on a total daily dose no greater than 150 mg/day (75 mg two times a day, or 50 mg three times a day). Based on individual patient response and tolerability, the dose may be increased to a maximum dose of 600 mg/day.

Management of Fibromyalgia: The recommended dose of Pregabalin for fibromyalgia is 300 to 450 mg/day. Dosing should begin at 75 mg two times a day (150 mg/day) and may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability.

Neuropathic pain associated with spinal cord injury: The recommended dose range is 150 to 600 mg/day. The recommended starting dose is 75 mg two times a day (150 mg/day). The dose may be increased to 150 mg two times a day (300 mg/day) within 1 week based on efficacy and tolerability.

Pregabalin capsules can be taken without regards to meals.

 

Interaction

Pregabalin has no noteworthy interactions with other antiepileptic medicines or oral contraceptives. The effects of ethanol and lorazepam may be amplified by pregabalin.

 

Contraindications

Patients who have a known hypersensitivity to Pregabalin or any of its components should avoid taking it.

 

Side Effects

Dizziness, somnolence, dry mouth, edema, blurred vision, weight gain, and aberrant thinking are the most common adverse effects.

 

Pregnancy & Lactation

Pregabalin has a pregnancy category of C. As a result, it should only be taken if the potential benefit outweighs the dangers to the fetus.

Pregabalin, like other medicines, can pass into the breast milk, thus it should only be used in nursing mothers if the benefits clearly outweigh the risks.

 

Precautions & Warnings

Pregabalin withdrawal without tapering might cause insomnia, nausea, headaches, and diarrhea. As a result, rather than stopping abruptly, it should be tapered gradually over a minimum of one week. If you use Pregabalin, your creatinine kinase level may rise. If myopathy is detected or suspected, or if creatinine kinase levels are abnormally high, it should be stopped immediately.

 

Therapeutic Class

Adjunct anti-epileptic drugs

 

Storage Conditions

Keep in a cool & dry place (below 30° C), protected from light & moisture. Keep out of the reach of children.

 

Pharmaceutical Name

ACME Laboratories Ltd.