Generic

Vitamin B1, B6 & B12

Indications

This combination may be used in-

▪ Chronic pains like sciatica

▪ Lumbago

▪ Trigeminal neuralgia

▪ Facial paralysis

▪ Optic neuritis

▪ As well as neuropathy & cardiac complications.

Besides these, this combination may be used in the deficiency of these vitamins.

Pharmacology

This is a combined preparation of Vitamin B1 (Thiamine Mononitrate), Vitamin B6 (Pyridoxine Hydrochloride) and Vitamin B12 (Cyanocobalamin). These vitamins play an essential role as coenzyme in the metabolism of nervous system. supports the regeneration of nerve fibers and myelin sheath by activation of the nerve cell metabolism and the natural repair mechanism. The combination of these three vitamins shows better efficacy than that of the individual components. In addition, Vitamin B1, Vitamin B6 & Vitamin B12 promote body’s own repair mechanism and work in pain management.

Dosage & Administration

Tablet: 1-3 Tablets per day or as advised by the physician.

Injection:

• In severe (acute) cases: 1 injection daily until the acute symptoms subside or taken as advised by the physician.
• In mild cases: 1 injection 2-3 times per week. Ampoules are preferably injected intramuscularly.

Use in children: There is no information on the use of this drug in children.

Interaction

Vitamin B6 (Pyridoxine Hydrochloride) reduces therapeutic effect of Levodopa but it does not occur if a dopa decarboxylase inhibitor is also given. Neomycin, Chloramphenicol, Aminosalisylic acid & H2 receptor antagonist may reduce Vitamin B12 absorption.

Contraindications

It should not be used in patients with known hypersensitivity to Thiamine, Cobalt or any other component of these preparations.

Side Effects

Very rarely hypersensitive reaction and sensitivity disturbance may occur.

Pregnancy & Lactation

No risks have become known associated with the use of this combination during pregnancy at the recommended dosage. Vitamin B1, B6 & B12 are secreted into the breast milk but risks of overdose for the infant are not known.

Precautions & Warnings

It should be avoided in case of hypersensitivity to Thiamine, Cobalt or any other component of these preparations. Cyanocobalamin should not be given before a diagnosis has been fully established because of the masking symptoms of subacute degeneration of the spinal cord.

Therapeutic Class

Vitamins and Minerals

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Pharmaceutical Name

Radiant Pharmaceuticals Limited