Indications

Clotrimazole rectal preparation is used to treat itching, burning, and discharge in the vaginal area caused by recurring vaginal yeast infections (Vaginal candidiasis), as well as vaginitis caused by Candida species and Mycotic infections worsened by other microorganisms responsive to the medicine.

Pharmacology of Neosten VT Vaginal Tablet

Clotrimazole is a broad-spectrum antifungal drug used to treat skin infections caused by a variety of pathogenic dermatophytes, yeasts, molds, and bacteria. Clotrimazole is also effective against Staphylococci and Trichomonas, which are gram-positive bacteria. Clotrimazole, like other imidazoles, interferes with cell wall lipids, altering the permeability of fungal cell walls. The principal action on fungi at static levels is suppression of ergosterol synthesis, but at higher concentrations, a secondary mechanism of membrane damage unrelated to sterol production occurs.

Dosage & Administration of Neosten VT Vaginal Tablet

Clotrimazole 100 mg & 200 mg vaginal preparation-

• First infections: In general, a 3-day treatment is sufficient for Candida vaginitis. On 3 consecutive nights, Clotrimazole 200 mg vaginal preparation is inserted as deeply as possible into the vagina. This is best achieved when lying on one’s back with the knees slightly bent.
• Re-infections: In general, a 6-day treatment is sufficient. This applies also to mixed infections with the above-mentioned causative organisms. On six consecutive nights, 1 Clotrimazole 100 mg vaginal preparation is inserted as deeply as possible into the vagina. If necessary, 2 Clotrimazole 100 mg (1 in the morning and 1 in the evening) or 1 Clotrimazole 200 mg daily can be used for 6-12 days. Treatment should be timed so as to avoid the menstrual period and be finished before the onset of menstruation. To avoid re-infection, the partner should undergo local treatment with Clotrimazole cream at the same time.

Clotrimazole 500 mg vaginal preparation: Single dose, complete treatment with one vaginal tablet. The tablet should be inserted as deeply as possible into the vagina. This is best achieved when lying on one’s back with the knees slightly bent. It is recommended that the treatment should be timed so as to avoid the menstrual period. For prevention of re-infection, the partner should be treated locally with Clotrimazole cream at the same time.

Clotrimazole vaginal preparation is colorless and does not stain the underwear.

Contraindications

It is contraindicated in patients with known hypersensitivity to any of the components of this product.

Side Effects of Neosten VT Vaginal Tablet

Since there is practically no Clotrimazole absorption through the vaginal skin, no systemic effect is expected. The local tolerance of Clotrimazole vaginal tablet is generally good. Local irritation or burning sensation may occur in very few cases but these symptoms are not considered harmful.

Pregnancy & Lactation

Clotrimazole should only be used during pregnancy if the doctor thinks it’s necessary. Clotrimazole is poorly absorbed into the bloodstream and body after being applied to the skin or vaginal area. No negative effects have been seen in studies of women in their second or third trimesters. Clotrimazole is not known to be secreted in breast milk. Clotrimazole suppositories can be used during pregnancy, but only with a physician’s approval.

Therapeutic Class

Drugs used in Vaginal and Vulval conditions, Topical Antifungal preparations

Storage Conditions

Protect from light and moisture by storing in a cool, dry place below 30°C. Keep out of children’s reach.

Pharmaceutical Name of Neosten VT Vaginal Tablet

Beximco Pharmaceuticals Ltd

Generic of Neosten VT Vaginal Tablet

Clotrimazole