Generic

Natamycin

Indications

Fungal blepharitis, conjunctivitis, and keratitis produced by susceptible organisms such as Fusarium solani are treated with natamycin sterile ophthalmic suspension.

Pharmacology

Streptomyces natalensis produces natamycin, a tetraene polyene antibiotic. Natamycin is thought to work by binding to sterols in the fungal cell membrane, causing a shift in membrane permeability that permits critical cellular elements to escape. It has in vitro activity against Candida, Aspergillus, Cephalosporium, Fusarium, and Penicillium, among other yeasts and filamentous fungus. Natamycin is primarily fungicidal, despite the fact that its efficacy against fungi is dose-dependent. Natamycin appears to be effectively concentrated within the corneal stroma but not in the intraocular fluid after topical application.

Dosage & Administration

For fungal keratitis: The preferred initial dosage is 1 drop instilled in the conjuntival sac (s) at 1-2 hours interval. The frequency of application can usually be reduced to 1 drop 6-8 times daily after the first 3-4 days. Therapy should generally be continued for 14 to 21 days or until there is resolution of active fungal keratitis. In many cases, it may be helpful to reduce the dosage gradually at 4 to 7 days intervals to assure the replicating fungus has been eliminated.

For fungal blepharitis & conjunctivitis: Less frequent initial dosage, 1 drop 4-6 times daily may be sufficient.

Interaction

May increase spread of fungal eye infection when used with topical corticosteroid..

Contraindications

Individuals having a history of hypersensitivity to any of the ingredients in natamycin ophthalmic suspension should avoid it.

Side Effects

There have been reports of eye irritation, pain, edema, conjunctival chemosis, and hyperemia..

Pregnancy & Lactation

Natamycin sterile ophthalmic suspension should only be given to a pregnant woman if absolutely necessary.

It is unknown whether or whether this medicine is excreted in human milk. When Natamycin is given to a nursing woman, extreme caution should be used.

Precautions & Warnings

Only for topical application on the eyes. The failure of keratitis to improve after 7-10 days of treatment shows that the illness is caused by a bacterium that is resistant to natamycin.

Therapeutic Class

Ophthalmic antibacterial drugs

Storage Conditions

Store in a cool, dry location. Protect yourself from the sun. Do not allow yourself to become frozen. After opening the bottle, do not use it for more than one month.

Pharmaceutical Name

Aristopharma Ltd.