Mycofree 15 MG


Mycofree 15 MG


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Terbinafine tablet: This tablet is shown for the treatment of onychomycosis of the toenail or fingernail due to dermatophytes (tinea unguium).

Terbinafine cream: Parasitic contamination of the skin caused by Trichophyton (e.g. T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceus), Microsporum canis and Epidermophyton floccosum. Yeast diseases of the skin, mainly those caused by the class Candida (e.g. C. albicans). Pityriasis (tinea) versicolor due to Pityrosporum orbiculare (too known as Malassezia furfur).


Terbinafine, an Allylamine antifungal, represses the biosynthesis of Ergosterol (a basic component of the fungal cell layer) through the hindrance of Squalene Epoxidase chemical. This comes about in parasitic cell passing fundamentally due to the expanded film porousness intervened by the collection of tall concentrations of Squalene but not due to Ergosterol insufficiency. Depending on the concentration of the sedate and the contagious species test in vitro, Terbinafine hydrochloride may be fungicidal. Be that as it may, the clinical importance of in vitro information is obscure. Terbinafine has appeared to be dynamic against most strains of the taking-after microorganisms both in vitro and in clinical diseases: Trichophyton Mentagrophyte, and Trichophyton rubrum.

Dosage & Administration

Terbinafine tablet: 

  • For the treatment of fingernail onychomycosis: Terbinafine 250 mg (one tablet), once day by day for 6 weeks.
  • For the treatment of toenail onychomycosis: Terbinafine 250 mg (one tablet), once day by day for 12 weeks.
  • The ideal clinical impact is seen a few months after mycological remedy and cessation of treatment. Usually related to the period required for outgrowth of the sound nail.

Terbinafine cream: Terbinafine cream can be connected once or twice every day. Cleanse and dry the influenced zones completely sometime recently with the application of the terbinafine cream. Apply the cream to the influenced skin and the encompassing zone in a lean layer and rub in gently. Within the case of intertriginous contaminations (submammary, interdigital, intergluteal, inguinal) the application may be secured with a dressing strip, particularly at night. The likely lengths of treatment are as takes after:

  • Tinea corporis, cruris: 1 to 2 weeks
  • Tinea pedis: 1 week
  • Cutaneous candidiasis: 2 weeks
  • Pityriasis Versicolor: 2 weeks
  • Relief of the clinical side effects ordinarily happens within a number of days. Unpredictable utilization or untimely suspension of treatment carries the hazard of repeat.
 If there are no signs of advancement after two weeks, the determination ought to be confirmed.


In vivo ponders have appeared that terbinafine is an inhibitor of the CYP450 2D6 isozyme. Drugs transcendently metabolized by the CYP450 2D6 isozyme incorporate the taking after medicating classes: tricyclic antidepressants, specific serotonin reuptake inhibitors, beta-blockers, antiarrhythmics lesson 1C (e.g., flecainide and propafenone) and monoamine oxidase inhibitors Sort B. Co-administration of terbinafine ought to be done with cautious observing and may require a diminishment in measurements of the 2D6-metabolized sedate.


Terbinafine tablets and creams are contra-indicated in people with easily affected by terbinafine.

Side Effects

The antagonistic occasions detailed include gastrointestinal side effects (counting loose bowels, dyspepsia, and stomach torment), liver test variations from the norm, rashes, urticaria, pruritus, and taste unsettling influences. In common, the unfavorable occasions were gentle, and temporal, and did not lead to cessation. Antagonistic occasions, based on world encounter with terbinafine utilize, incorporate: quirky and symptomatic hepatic harm and more seldom, cases of liver disappointment, a few driving to passing or liver transplant, genuine skin responses, extreme neutropenia, thrombocytopenia, angioedema and unfavorably susceptible responses (counting anaphylaxis). Other unfavorable responses that have been detailed incorporate discomfort, weariness, spewing, arthralgia, myalgia, and hair misfortune.

Pregnancy & Lactation

Terbinafine tablet: There are no satisfactory and well-controlled things about in pregnant ladies. Since creature propagation ponders are not continuously prescient of human reaction, as a result, treatment of onychomycosis can be put off until after pregnancy is completed, it is suggested that terbinafine not be initiated amid pregnancy. After verbal organization, terbinafine is shown within the breast drain of nursing moms. Treatment with terbinafine isn’t prescribed in nursing moms.

Terbinafine cream: Fetal poisonous quality and ripeness ponder in creatures propose no unfavorable impacts. There’s no clinical involvement with terbinafine in pregnant ladies; in this manner, unless the potential benefits exceed any potential hazard, terbinafine ought to not be managed. Terbinafine is excreted in the breast drain and so moms ought to not get terbinafine treatment while breastfeeding.

Precautions & Warnings


Terbinafine tablets: Uncommon cases of liver disappointment, a few driving to passing or liver transplant, have happened with the utilization of terbinafine tablets for the treatment of onychomycosis in people with and without preexisting liver illness. Within the larger part of liver cases detailed in affiliation with terbinafine utilization, the patients had genuine basic systemic conditions and a questionable causal affiliation with terbinafine. The seriousness of hepatic occasions and/or their result may be more regrettable in patients with dynamic or persistent liver illness. Treatment with terbinafine tablets should be suspended on the off chance that there’s a biochemical or clinical proof of liver damage. There have been confined reports of genuine skin response (e.g., Stevens-Johnson Disorder and poisonous epidermal necrolysis). On the off chance that dynamic skin hasty happens, treatment with terbinafine ought to be suspended.

Terbinafine cream: Terbinafine cream is for outside utilize as it were. Contact with the eyes ought to be avoided.


Terbinafine is not suggested for patients with persistent or dynamic liver illness. Sometime recently endorsing Terbinafine, pre-existing liver infection ought to be surveyed. Hepatotoxicity may happen in patients with and without pre-existing liver infections. Pretreatment serum transaminase (ALT and AST) tests are exhorted for all patients sometime recently taking terbinafine tablets.

Therapeutic Class

Drugs for subcutaneous and mycoses, Topical Antifungal preparations

Storage Conditions

Store in a cool and dry placebelow 30°C, secure from light.


Terbinafine Hydrochloride

Pharmaceutical Name

Drug International Ltd.