Generic

Moxifloxacin Hydrochloride + Dexamethasone

Indications

Moxigen-D Eye Drops is indicated in the treatment of eye infections caused by
susceptible microorganisms and in the prevention of inflammation and bacterial infection
that may occur after eye surgery.

Pharmacology

The antibacterial action of Moxifloxacin results from inhibition of DNA gyrase and
topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication,
transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play
a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Through inhibiting this process Moxifloxacin shows bactericidal activity.
The action of Dexamethasone is to inhibit the phospholipase A2, the first step in
prostaglandin synthesis. Also, inhibits the chemotactic infiltration of neutrophils into the
site of inflammation. Its anti-inflammatory activity is 30 times greater and its overall
therapeutic effectiveness 8-10 times greater than that of hydrocortisone. Like other
glucocorticoids, it is anti-allergic, anti-exudative and anti-proliferative.

Dosage & Administration

In the prevention of infection and post-surgical ocular inflammation: Instill 1 drop, 4 times
a day, in the eye to be operated, from 1 day before surgery until 15 days after surgery.
In patients undergoing cataract surgery: The day of surgery instill the medication
immediately after eye surgery.
In patients undergoing LASIK refractive surgery: On the day of surgery instill the
medication at least 15 minutes after ocular surgery.
In eye infections caused by susceptible microorganisms: Instill 1 drop, 4 times a day, for
up to 7 days.

Contraindications

Contraindicated in fungal disease of ocular structures, viral conjunctivitis and
hypersensitivity to any of the components of the formulation.

Side Effects

Moxifloxacin: Conjunctivitis decreased visual acuity, dry eye, keratitis, Ocular discomfort,
hyperemia, pain, Subconjunctival hemorrhage and tearing.

Dexamethasone: Visual acuity & field defects, cataract formation, secondary ocular
infection following suppression of host response & perforation of the globe.

Pregnancy & Lactation

Use in pregnancy: There are no adequate and well-controlled studies in pregnant
women. Moxifloxacin & Dexamethasone combination eye drops should be used during
pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in elderly: No change in dosage is required when the product is administered in
elderly patients.
Use in Children: The Efficacy and safety of Moxifloxacin & Dexamethasone combination
eye drops in pediatric patients have not been established.
Use in lactation: Caution is advised when Moxifloxacin & Dexamethasone combination
eye drops is given to nursing women.

Precautions & Warnings

Only for ophthalmological usage. However, neither under the conjunctiva nor directly into your anterior chamber is advised. Ocular hypertension can develop as a result of prolonged usage of steroids.

Therapeutic Class

Ophthalmic Steroid preparations

Storage Conditions

Pharmaceutical Name

General Pharmaceuticals Ltd.